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Abstract
Hirano bodies are intraneuronal inclusions whose frequency increases with age and
Alzheimer's disease. These paracrystalline inclusions have been shown previously using
immunocytochemistry to share epitopes with actin, tropomyosin, alpha-actinin and vinculin.
Hirano bodies have not previously been demonstrated to share components with neurofibrillary
tangles, another intraneuronal inclusion characteristic of Alzheimer's disease. In
this study, we show that Hirano bodies bind antibodies to the microtubule-associated
protein tau, a component of Alzheimer neurofibrillary tangles.