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      Photo-curing 3D printing technique and its challenges

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          Abstract

          In recent ten years, 3D printing technology has been developed rapidly. As an advanced technology, 3D printing has been used to fabricate complex and high-precision objects in many fields. 3D printing has several technologies. Among these technologies, photo-curing 3D printing was the earliest and most mature technology. In 1988, the first 3D printing machine which was based on photo-curing and called Stereo lithography Appearance (SLA) technology was produced by 3D system Corp. After 30 years of development, many new technologies based on photocuring mechanism emerged. Based on the different principle of pattern formation and character of printing technology, numerous photocuring 3D printing techniques, such as SLA, DLP, LCD, CLIP, MJP, two-photon 3D printing, holographic 3D printing and so on, have been developed. Photo-curing 3D printing has many advantages, such as high precision, smooth surface of printing objects, rapid printing speed and so on. Here, we would introduce five industrial photocuring 3D printing technologies, which are SLA, DLP, LCD, CLIP and MJP. The characters of the materials and the progress of the application of the technique in the biomedical field is also overviewed. At last, the difficulties and challenges of photo-curing 3D printing are also discussed.

          Highlights

          • Different techniques of photocuring 3D printing were overviewed.

          • The advantage, disadvantage and application of the different techniques of photocuring 3D printing were discussed.

          • The progress of photocuring 3D printing technique in biomedical application is commented.

          • The existing problems and challenges of photocuring 3D printing were presented.

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          Most cited references19

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          Additive manufacturing. Continuous liquid interface production of 3D objects.

          Additive manufacturing processes such as 3D printing use time-consuming, stepwise layer-by-layer approaches to object fabrication. We demonstrate the continuous generation of monolithic polymeric parts up to tens of centimeters in size with feature resolution below 100 micrometers. Continuous liquid interface production is achieved with an oxygen-permeable window below the ultraviolet image projection plane, which creates a "dead zone" (persistent liquid interface) where photopolymerization is inhibited between the window and the polymerizing part. We delineate critical control parameters and show that complex solid parts can be drawn out of the resin at rates of hundreds of millimeters per hour. These print speeds allow parts to be produced in minutes instead of hours.
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            Stereolithographic (SLA) 3D printing of oral modified-release dosage forms

            The aim of this work was to evaluate the suitability of stereolithography (SLA) to fabricate drug-loaded tablets with modified-release characteristics. The SLA printer creates solid objects by using a laser beam to photopolymerise monomers. In this work polyethylene glycol diacrylate (PEGDA) was used as a monomer and diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide was used as a photo-initiator. 4-aminosalicylic acid (4-ASA) and paracetamol (acetaminophen) were selected as model drugs. Tablets were successfully printed and formulations with different properties were fabricated by adding polyethylene glycol 300 (PEG 300) to the printing solution. The loading of paracetamol and 4-ASA in the printed tablets was 5.69% and 5.40% respectively. In a realistic dynamic dissolution simulation of the gastrointestinal tract, drug release from the tablets was dependent on the composition of the formulations, but independent of dissolution pH. In conclusion SLA 3DP technology allows the manufacture of drug loaded tablets with specific extended-release profiles. In the future this technology could become a manufacturing technology for the elaboration of oral dosage forms, for industrial production or even for personalised dose.
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              Laser 3D Printing with Sub-Microscale Resolution of Porous Elastomeric Scaffolds for Supporting Human Bone Stem Cells

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                Author and article information

                Contributors
                Journal
                Bioact Mater
                Bioact Mater
                Bioactive Materials
                KeAi Publishing
                2452-199X
                22 January 2020
                March 2020
                22 January 2020
                : 5
                : 1
                : 110-115
                Affiliations
                [1]College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, PR China
                Author notes
                []Corresponding author. zhuxq@ 123456mail.buct.edu.cn
                Article
                S2452-199X(19)30071-4
                10.1016/j.bioactmat.2019.12.003
                6992881
                32021945
                37cfcf86-579b-470e-962b-b5657a4eb53b
                © 2020 Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 22 August 2019
                : 9 December 2019
                : 9 December 2019
                Categories
                Article

                3d printing,photo-curing,biomedical applications
                3d printing, photo-curing, biomedical applications

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