Self-assembled CeVO 4 /Au heterojunction nanocrystals for photothermal/photoacoustic bimodal imaging-guided phototherapy† – ScienceOpen
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      Self-assembled CeVO 4/Au heterojunction nanocrystals for photothermal/photoacoustic bimodal imaging-guided phototherapy†

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      , , ,
      RSC Advances
      The Royal Society of Chemistry

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          Abstract

          Phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), has attracted great attention because it can effectively inhibit the proliferation and propagation of cancer cells. Recently, heterojunction nanomaterials have shown tremendous application value in the field of biological medicine. In this work, the CeVO 4/Au heterojunction nanocrystals (NCs) are designed for photothermal/photoacoustic bimodal imaging-guided phototherapy. The as-synthesized hydrophobic oleic acid (OA)-stabilized CeVO 4 nanosheets were modified with HS-PEG-OH for translating into hydrophilic ones, which can significantly improve their stability and biocompatibility. Subsequently, the plasmonic Au nanoparticles were in situ successfully deposited on the surface of HS-PEG-coated CeVO 4 to form CeVO 4/Au heterojunction NCs for improving the visible and near-infrared light absorption, which results in enhanced photothermal conversion performance and reactive oxygen species (ROS) generation capacity. Thus, the CeVO 4/Au can cause more severe damage to cancer cells than pure CeVO 4 under NIR laser irradiation. Also, CeVO 4/Au can provide distinct tumor contrast by photothermal/photoacoustic bimodal bioimaging. Our results demonstrate that CeVO 4/Au NCs could be used as an effective theranostic anticancer agent for near-infrared (NIR) light-mediated PTT and PDT.

          Abstract

          CeVO 4/Au NCs can be used as an effective photothermal/photoacoustic bimodal imaging-guided theranostic anticancer agent for near-infrared (NIR) light-mediated photothermal/photodynamic therapy.

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          Author and article information

          Journal
          RSC Adv
          RSC Adv
          RA
          RSCACL
          RSC Advances
          The Royal Society of Chemistry
          2046-2069
          14 January 2020
          14 January 2020
          14 January 2020
          : 10
          : 5
          : 2581-2588
          Affiliations
          [a] Department of Obstetrics and Gynecology, China-Japan Union Hospital of Jilin University Changchun Jilin 130033 China zhanggs576@ 123456163.com
          [b] Department of Anesthesiology, China-Japan Union Hospital of Jilin University Changchun Jilin 130033 China
          Author information
          https://orcid.org/0000-0001-8444-7106
          Article
          c9ra09860g
          10.1039/c9ra09860g
          9048972
          35496088
          37859279-cf95-4616-9428-dc08c9df95b8
          This journal is © The Royal Society of Chemistry
          History
          : 25 November 2019
          : 4 January 2020
          Page count
          Pages: 8
          Funding
          Funded by: Department of Science and Technology of Jilin Province, doi 10.13039/501100011789;
          Award ID: 20190201003
          Award ID: 3D518NU13430
          Categories
          Chemistry
          Custom metadata
          Paginated Article

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