Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation

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Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis.

George Cotsarelis, Tung-Tien Sun, Robert Lavker (1990)

Inconsistent with the view that hair follicle stem cells reside in the matrix area of the hair bulb, we found that label-retaining cells exist exclusively in the bulge area of the mouse hair follicle. The bulge consists of a subpopulation of outer root sheath cells located in the midportion of the follicle at the arrector pili muscle attachment site. Keratinocytes in the bulge area are relatively undifferentiated ultrastructurally. They are normally slow cycling, but can be stimulated to proliferate transiently by TPA. Located in a well-protected and nourished environment, these cells mark the lower end of the "permanent" portion of the follicle. Our findings, plus a reevaluation of the literature, suggest that follicular stem cells reside in the bulge region, instead of the lower bulb. This new view provides insights into hair cycle control and the possible involvement of hair follicle stem cells in skin carcinogenesis.

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Epidermal homeostasis: a balancing act of stem cells in the skin.

Cédric Blanpain, Elaine Fuchs (2009)

The skin epidermis and its array of appendages undergo ongoing renewal by a process called homeostasis. Stem cells in the epidermis have a crucial role in maintaining tissue homeostasis by providing new cells to replace those that are constantly lost during tissue turnover or following injury. Different resident skin stem cell pools contribute to the maintenance and repair of the various epidermal tissues of the skin, including interfollicular epidermis, hair follicles and sebaceous glands. Interestingly, the basic mechanisms and signalling pathways that orchestrate epithelial morphogenesis in the skin are reused during adult life to regulate skin homeostasis.

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Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.

Lynn Petukhova, Madeleine Duvic, Maria Hordinsky … (2010)

Alopecia areata (AA) is among the most highly prevalent human autoimmune diseases, leading to disfiguring hair loss due to the collapse of immune privilege of the hair follicle and subsequent autoimmune attack. The genetic basis of AA is largely unknown. We undertook a genome-wide association study (GWAS) in a sample of 1,054 cases and 3,278 controls and identified 139 single nucleotide polymorphisms that are significantly associated with AA (P

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Author and article information

Journal

Title: Cell

Abbreviated Title: Cell

Publisher: Elsevier BV

ISSN (Print): 00928674

Publication date Created: June 2017

Publication date (Print): June 2017

Volume: 169

Issue: 6

Pages: 1119-1129.e11

Article

DOI: 10.1016/j.cell.2017.05.002

PMC ID: 5504703

PubMed ID: 28552347

SO-VID: 371a3903-265d-4b0d-bf1c-ccd55767fbed

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