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Nosocomial superinfections due to linezolid-resistant Enterococcus faecalis: evidence for a gene dosage effect on linezolid MICs
Kathleen A. Ruggero ,
Laura K. Schroeder ,
Paul C. Schreckenberger ,
Alexander S. Mankin ,
John P. Quinn
November 2003
November 2003
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Abstract
Resistance to linezolid among Enterococcus faecium and Enterococcus faecalis isolates
has been reported in patients who receive a prolonged course of the drug. We report
two cases of linezolid-resistant Enterococcus faecalis that occurred in patients who
previously received linezolid for infections with vancomycin-resistant Enterococcus
faecium. Both isolates had the G2576U mutation in the 23S rRNA previously reported
in isolates of Enterococcus faecium. The number of gene copies mutated in the 23S
rRNA correlated with the level of resistance.