Contributors
Hui-Hua Chang:
ORCID: http://orcid.org/0000-0001-6369-0326
Role: Formal analysisRole: InvestigationRole: Project administrationRole: VisualizationRole:
Writing – original draftRole: Writing – review & editing
Aune Moro: Role: Investigation
Kazuki Takakura: Role: Formal analysisRole: InvestigationRole: VisualizationRole: Writing – original
draft
Hsin-Yuan Su: Role: Formal analysisRole: InvestigationRole: Visualization
Allen Mo: Role: Formal analysisRole: Investigation
Masako Nakanishi: Role: Formal analysisRole: InvestigationRole: VisualizationRole: Writing – original
draft
Richard T. Waldron: Role: Formal analysisRole: Investigation
Samuel W. French: Role: Formal analysisRole: Investigation
David W. Dawson: Role: Formal analysisRole: Investigation
O. Joe Hines: Role: ConceptualizationRole: Supervision
Gang Li: Role: Formal analysis
Vay Liang W. Go: Role: ConceptualizationRole: Supervision
James Sinnett-Smith: Role: Investigation
Stephen J. Pandol: Role: ConceptualizationRole: Funding acquisitionRole: Supervision
Aurelia Lugea: Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole:
Project administrationRole: SupervisionRole: VisualizationRole: Writing – original
draftRole: Writing – review & editing
Anna S. Gukovskaya: Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: Project
administrationRole: SupervisionRole: ValidationRole: Writing – original draftRole:
Writing – review & editing
Michael O. Duff: Role: Formal analysisRole: InvestigationRole: Software
Daniel W. Rosenberg: Role: Project administrationRole: SupervisionRole: Writing – review & editing
Enrique Rozengurt: Role: ConceptualizationRole: Funding acquisitionRole: SupervisionRole: Writing – review
& editing
Guido Eibl: Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: Project
administrationRole: SupervisionRole: VisualizationRole: Writing – original draftRole:
Writing – review & editing
Ilse Rooman: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
8
September
2017
Publication date Collection: 2017
Volume: 12
Issue: 9
Electronic Location Identifier: e0184455
Affiliations
[1
]
Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, United
States of America
[2
]
Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine
at UCLA, Los Angeles, CA, United States of America
[3
]
Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, United States
of America
[4
]
Pancreatic Research Group, Department of Medicine, Cedars-Sinai Medical Center, Los
Angeles, CA, United States of America
[5
]
Center for Molecular Oncology, UCONN Health, Farmington, CT, United States of America
[6
]
Department of Pathology, Harbor-UCLA Medical Center, Torrance, CA, United States of
America
[7
]
Southern California Research Center for ALPD and Cirrhosis, Department of Pathology,
Keck School of Medicine of the University of Southern California, Los Angeles, CA,
United States of America
[8
]
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at
UCLA, Los Angeles, CA, United States of America
[9
]
Department of Biostatistics, School of Public Health at UCLA, Los Angeles, CA, United
States of America
[10
]
Department of Genetics and Genome Sciences, UCONN Health, Farmington, CT, United States
of America
Vrije Universiteit Brussel, BELGIUM
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PONE-D-17-13311
DOI: 10.1371/journal.pone.0184455
PMC ID: 5590955
PubMed ID: 28886117
SO-VID: 36289732-4152-4a46-a17a-1a34323a7fdd
Copyright © © 2017 Chang et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 5
April
2017
Date
accepted
: 24
August
2017
Page count
Figures: 7,
Tables: 3,
Pages: 22
Funding
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: P01 CA163200
Award Recipient
:
Guido Eibl
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: R01 AA019954
Award Recipient
:
Aurelia Lugea
Funded by: NIDDK-supported CURE: Digestive Diseases Research Core Center Grant
Award ID: P30DK41301
Award Recipient
:
Enrique Rozengurt
Funded by: Hirshberg Foundation for Pancreatic Cancer Research
Award Recipient
:
Guido Eibl
This research was funded by the National Institute of Health (P01 CA163200 to GE and
R01 AA019954 to AL), the NIDDK-supported CURE: Digestive Diseases Research Core Center
Grant (P30DK41301 to ER), and the Hirshberg Foundation for Pancreatic Cancer Research
(
http://pancreatic.org/). The funders had no role in study design, data collection and analysis, decision
to publish, or preparation of the manuscript.
Categories
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancers and Neoplasms
Subject:
Gastrointestinal Tumors
Subject:
Pancreatic Cancer
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Inflammation
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Inflammation
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Signs and Symptoms
Subject:
Inflammation
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Signs and Symptoms
Subject:
Inflammation
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Physiological Parameters
Subject:
Body Weight
Subject:
Obesity
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Physiological Parameters
Subject:
Body Weight
Subject:
Obesity
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Endocrine System
Subject:
Pancreas
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Endocrine System
Subject:
Pancreas
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Exocrine Glands
Subject:
Pancreas
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Exocrine Glands
Subject:
Pancreas
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cell Processes
Subject:
Cell Death
Subject:
Autophagic Cell Death
Subject:
Biology and Life Sciences
Subject:
Nutrition
Subject:
Diet
Subject:
Medicine and Health Sciences
Subject:
Nutrition
Subject:
Diet
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Signs and Symptoms
Subject:
Lesions
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Signs and Symptoms
Subject:
Lesions
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Transmembrane Transport Proteins
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