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      G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders

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          Abstract

          Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors. Identifying treatment targets is challenging because the diseases are resulting from heterogeneous biological, genetic, and environmental factors. Nevertheless, the increasing understanding of G protein-coupled receptor (GPCR) opens a new possibility in drug discovery. Harnessing our knowledge of molecular mechanisms and structural information of GPCRs will be advantageous for developing effective drugs. This review provides an overview of the role of GPCRs in various neurodegenerative and psychiatric diseases. Besides, we highlight the emerging opportunities of novel GPCR targets and address recent progress in GPCR drug development.

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          Most cited references808

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          The Protein Data Bank.

          H M Berman, J Westbrook, Z. Feng … (2000)
          The Protein Data Bank (PDB; http://www.rcsb.org/pdb/ ) is the single worldwide archive of structural data of biological macromolecules. This paper describes the goals of the PDB, the systems in place for data deposition and access, how to obtain further information, and near-term plans for the future development of the resource.
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            The role of inflammation in depression: from evolutionary imperative to modern treatment target.

            Andrew Miller, Charles L. Raison (2016)
            Crosstalk between inflammatory pathways and neurocircuits in the brain can lead to behavioural responses, such as avoidance and alarm, that are likely to have provided early humans with an evolutionary advantage in their interactions with pathogens and predators. However, in modern times, such interactions between inflammation and the brain appear to drive the development of depression and may contribute to non-responsiveness to current antidepressant therapies. Recent data have elucidated the mechanisms by which the innate and adaptive immune systems interact with neurotransmitters and neurocircuits to influence the risk for depression. Here, we detail our current understanding of these pathways and discuss the therapeutic potential of targeting the immune system to treat depression.
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              Diagnosis and Treatment of Parkinson Disease: A Review

              Melissa Armstrong, Michael Okun (2020)
              Parkinson disease is the most common form of parkinsonism, a group of neurological disorders with Parkinson disease-like movement problems such as rigidity, slowness, and tremor. More than 6 million individuals worldwide have Parkinson disease.
              Article 0 comments Cited 722 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Honglin Li:
                ORCID: http://orcid.org/0000-0003-2270-1900
                hlli@ecust.edu.cn
                Song Wu: wusong@szu.edu.cn
                Yang Du:
                ORCID: http://orcid.org/0000-0001-8107-6397
                yangdu@cuhk.edu.cn
                Journal
                Journal ID (nlm-ta): Signal Transduct Target Ther
                Journal ID (iso-abbrev): Signal Transduct Target Ther
                Title: Signal Transduction and Targeted Therapy
                Publisher: Nature Publishing Group UK (London )
                ISSN (Print): 2095-9907
                ISSN (Electronic): 2059-3635
                Publication date (Electronic): 3 May 2023
                Publication date PMC-release: 3 May 2023
                Publication date Collection: 2023
                Volume: 8
                Electronic Location Identifier: 177
                Affiliations
                [1 ]GRID grid.10784.3a, ISNI 0000 0004 1937 0482, Kobilka Institute of Innovative Drug Discovery, Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Medicine, , The Chinese University of Hong Kong, ; 518172 Shenzhen, Guangdong China
                [2 ]GRID grid.12527.33, ISNI 0000 0001 0662 3178, School of Medicine, , Tsinghua University, ; 100084 Beijing, China
                [3 ]GRID grid.263488.3, ISNI 0000 0001 0472 9649, Institute of Urology, The Affiliated Luohu Hospital of Shenzhen University, , Shenzhen University, ; 518000 Shenzhen, Guangdong China
                [4 ]GRID grid.28056.39, ISNI 0000 0001 2163 4895, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, , East China University of Science and Technology, ; 200237 Shanghai, China
                [5 ]GRID grid.22069.3f, ISNI 0000 0004 0369 6365, Innovation Center for AI and Drug Discovery, , East China Normal University, ; 200062 Shanghai, China
                [6 ]GRID grid.263488.3, ISNI 0000 0001 0472 9649, Department of Urology, South China Hospital, Health Science Center, , Shenzhen University, ; 518116 Shenzhen, Guangdong China
                Author information
                http://orcid.org/0000-0003-4414-237X
                http://orcid.org/0000-0003-2270-1900
                http://orcid.org/0000-0001-8107-6397
                Article
                Publisher ID: 1427
                DOI: 10.1038/s41392-023-01427-2
                PMC ID: 10154768
                PubMed ID: 37137892
                SO-VID: 3623b74e-0141-4d96-b06e-54d628466655
                Copyright © © The Author(s) 2023
                License:

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

                History
                Date received : 8 July 2022
                Date revision received : 17 February 2023
                Date accepted : 30 March 2023
                Funding
                Funded by: Science, Technology and Innovation Commission of Shenzhen Municipality (Project code JCYJ20200109150019113, GXWD20201231105722002); The Kobilka Institute of Innovative Drug Discovery and Presidential Fellowship at the Chinese University of Hong Kong, Shenzhen, China; National Natural Science Foundation of China (Project code 32271263 to Y. D., Project code 82173690 to S.L., 81825020 and 82150208 to H.L.) The Lingang Laboratory (Project code LG-QS-202206-02 to S.L.)
                Categories
                Subject: Review Article
                Custom metadata
                issue-copyright-statement © The Author(s) 2023

                Keywords: neuroscience,diseases of the nervous system
                Data availability:
                Keywords: neuroscience, diseases of the nervous system

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