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      Rosmarinus officinalis L. (rosemary) as therapeutic and prophylactic agent

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          Abstract

          Rosmarinus officinalis L. (rosemary) is a medicinal plant native to the Mediterranean region and cultivated around the world. Besides the therapeutic purpose, it is commonly used as a condiment and food preservative. R. officinalis L. is constituted by bioactive molecules, the phytocompounds, responsible for implement several pharmacological activities, such as anti-inflammatory, antioxidant, antimicrobial, antiproliferative, antitumor and protective, inhibitory and attenuating activities. Thus, in vivo and in vitro studies were presented in this Review, approaching the therapeutic and prophylactic effects of R. officinalis L. on some physiological disorders caused by biochemical, chemical or biological agents. In this way, methodology, mechanisms, results, and conclusions were described. The main objective of this study was showing that plant products could be equivalent to the available medicines.

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                Author and article information

                Contributors
                +55 12 3947-9334 , jroliveira16@hotmail.com
                scamargo@dental.ufl.edu
                luciane@ict.unesp.br
                Journal
                J Biomed Sci
                J. Biomed. Sci
                Journal of Biomedical Science
                BioMed Central (London )
                1021-7770
                1423-0127
                9 January 2019
                9 January 2019
                2019
                : 26
                : 5
                Affiliations
                [1 ]ISNI 0000 0001 2188 478X, GRID grid.410543.7, Departamento de Biociências e Diagnóstico Bucal, Instituto de Ciência e Tecnologia, , Universidade Estadual Paulista (UNESP), ; Av. Engenheiro Francisco José Longo, 777 – Jardim São Dimas, São José dos Campos, SP CEP 12245-000 Brazil
                [2 ]ISNI 0000 0004 1936 8091, GRID grid.15276.37, Department of Restorative Dental Sciences, , University of Florida, College of Dentistry, ; Gainesville, FL 32610 USA
                Author information
                https://orcid.org/0000-0003-2398-6506
                https://orcid.org/0000-0002-2527-0651
                https://orcid.org/0000-0002-5465-9551
                Article
                499
                10.1186/s12929-019-0499-8
                6325740
                30621719
                35a477ae-a419-4e56-952b-14a23bd11015
                © The Author(s). 2019

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                : 26 July 2018
                : 2 January 2019
                Categories
                Review
                Custom metadata
                © The Author(s) 2019

                Molecular medicine
                rosmarinus officinalis l.,rosemary,biological activities,phytotherapy,therapeutic effects,prophylactic effects

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