GLP1 Receptor Agonists—Effects beyond Obesity and Diabetes

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Abstract

Glucagon-like peptide-1 receptor agonists (GLP1RA) have been transformative for patients and clinicians in treating type-2 diabetes and obesity. Drugs of this class, the bioavailability of which is continuously improving, enable weight loss and control blood glucose with minimal unwanted side effects. Since adopting GLP1RA for treating metabolic diseases, animal and clinical studies have revealed their beneficial effects on several other pathologies, including cardiovascular diseases, neurodegeneration, kidney disease, and cancer. A notable commonality between these diseases is their association with older age. Clinical trials and preclinical data suggest that GLP1RA may improve outcomes in these aging-related diseases. Some of the benefits of GLP1RA may be indirect due to their effects on obesity and glucose metabolism. However, there is building evidence that GLP1RA may also act directly on multiple organs implicated in aging-related pathology. This review aims to compile the studies reporting the effects of GLP1RA on aging-related diseases and discuss potential underlying mechanisms.

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Steven P Marso, Gilbert H Daniels, Kirstine Brown-Frandsen … (2016)

The cardiovascular effect of liraglutide, a glucagon-like peptide 1 analogue, when added to standard care in patients with type 2 diabetes, remains unknown.

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Author and article information

Contributors

Mikhail G. Kolonin: (View ORCID Profile)

Journal

Journal ID (publisher-id): CELLC6

Title: Cells

Abbreviated Title: Cells

Publisher: MDPI AG

ISSN (Electronic): 2073-4409

Publication date Created: January 2024

Publication date (Electronic): December 28 2023

Volume: 13

Issue: 1

Page: 65

Article

DOI: 10.3390/cells13010065

PubMed ID: 38201269

SO-VID: 35126f3d-e2c7-48d6-8986-ac724febffb2

License:

https://creativecommons.org/licenses/by/4.0/

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