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Abstract
Various circular RNAs (circRNAs) have been reported to involve in carcinoma. This
study explored the role and mechanism of circRNA circFNDC3B (circFNDC3B) in renal
carcinoma (RC). The detection indicators in this paper were viability, colony, and
migration, which respectively investigated by Cell Counting Kit-8, colony formation,
and migration assay. Reverse transcriptase quantitative polymerase chain reaction
tested and cell transfection changed circFNDC3B and miR-99a expression. Moreover,
western blot tested relate-proteins of proliferation, migration, and cell pathways
were examined by western blot. circFNDC3B was upregulated at RC tissues. circFNDC3B
enhanced cell viability, colony and migration, and miR-99a mimic played reverse impacts.
Furthermore, circFNDC3B negatively regulated miR-99aand circFNDC3B restrained the
janus kinase 1/signal transducer and activator of transcription 3 (JAK1/STAT3) and
extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK pathways by miR-99a downregulation.
Overexpression of circFNDC3B enhanced cell viability, colony formation and migration
by miR-99a downregulation via JAK1/STAT3 and MEK/ERK pathways.