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      Multiple three-column osteotomies successfully correcting cervicothoracic kyphosis in the setting of ankylosing spondylitis: illustrative case

      case-report

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          Abstract

          BACKGROUND

          Ankylosing spondylitis (AS) is an autoimmune spondylarthritis often associated with rigid kyphoscoliosis. The authors describe a surgical approach that employs multilevel three-column osteotomies for the restoration of normal global alignment.

          OBSERVATIONS

          A 48-year-old male with a past medical history of AS presented to the clinic with a stooped-over posture: his chin-brow vertical angle (CBVA) was 58.0°; T1 slope (T1S), 97.8°; thoracic kyphosis (TK; T1–12), 94.2°; proximal TK (T1–5), 50.8°; distal TK (T5–12), 43.5°; and sagittal vertical axis (SVA), 22.6 cm. A two-stage procedure was planned. During stage 1, instrumentation was placed from C5 to T10, followed by a T3 vertebral column resection. During stage 2, bilateral pedicle screws were placed from T11 to the pelvis. An L3 pedicle subtraction osteotomy (PSO) was completed and was followed by a T7 PSO. Postoperatively, the patient had significant postural improvement: CBVA was 29.3°; T1S, 57.8°; TK, 77.3°; proximal TK, 33.5°; distal TK, 43.8°; and SVA, 15 cm. At 6 years postoperatively, the patient continued to do well and was without evidence of construct breakdown.

          LESSONS

          The authors propose that multilevel three-column osteotomies, if optimally located, successfully correct spinal malalignment associated with AS.

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          Most cited references21

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          Global Alignment and Proportion (GAP) Score: Development and Validation of a New Method of Analyzing Spinopelvic Alignment to Predict Mechanical Complications After Adult Spinal Deformity Surgery

          The restoration of normal sagittal alignment is a critical goal in adult spinal deformity surgery to achieve favorable outcomes and prevent mechanical complications. Schwab sagittal modifiers have been accepted as targets for appropriate alignment, but addressing these targets does not always prevent high mechanical complication or revision rates. This may be because the linear absolute numerical parameters do not cover the whole pelvic incidence spectrum and the distribution of lordosis, pelvic anteversion, and negative malalignment are not considered as potential causes of failure. The aim of the present study was to develop and validate a score based on pelvic-incidence-based proportional parameters to better predict mechanical complications.
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            Age-related hyperkyphosis: update of its potential causes and clinical impacts-narrative review.

            The present study aims to qualitatively review the contributing factors and health implications of age-related hyperkyphosis. We conducted a narrative review of observational and cohort studies describing the risk factors and epidemiology of hyperkyphosis from 1955 to 2016 using the following key words: kyphosis, hyperkyphosis, posture, age-related hyperkyphosis, kyphotic posture, aetiology and causes. This review included 77 studies. Approximately 60-70 % of the most severe hyperkyphosis cases have no evidence of underlying vertebral compression fractures. Other proposed factors contributing to hyperkyphosis are degenerative disc disease, weakness of back extensor muscles and genetic predisposition. Strength and endurance of back extensor muscles are very important for maintaining normal postural alignment. Recent evidence suggests that age-related hyperkyphosis is not equivalent to spinal osteoporosis. Due to the negative impact of hyperkyphosis on physical function, quality of life and mortality rates, physicians should focus not only on osteoporosis, but also on age-related postural changes. More research about the relationship between spinal morphology and modifiable factors, especially the structural and functional parameters of trunk muscles, could further illuminate our understanding and treatment options for hyperkyphosis.
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              • Record: found
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              Osteoimmunological insights into the pathogenesis of ankylosing spondylitis

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                Author and article information

                Journal
                J Neurosurg Case Lessons
                J Neurosurg Case Lessons
                J Neurosurg Case Lessons
                Journal of Neurosurgery: Case Lessons
                American Association of Neurological Surgeons
                2694-1902
                11 March 2024
                11 March 2024
                : 7
                : 11
                : CASE23708
                Affiliations
                [1 ]Department of Neurosurgery, Inova Neuroscience and Spine Institute, Falls Church, Virginia; and
                [2 ]Department of Neurosurgery, Long Island Brain and Spine, New York, New York
                Author notes
                CorrespondenceLuke Mugge: Inova Neuroscience and Spine Institute, Falls Church, VA. lukealan.mugge@ 123456inova.org .

                INCLUDE WHEN CITING Published March 11, 2024; DOI: 10.3171/CASE23708.

                Disclosures The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.

                Article
                CASE23708
                10.3171/CASE23708
                10936943
                38467052
                34f0705e-d06c-49c9-b7bc-031682b08af1
                © 2024 The authors

                CC BY-NC-ND 4.0 ( http://creativecommons.org/licenses/by-nc-nd/4.0/)

                History
                : 29 November 2023
                : 6 February 2024
                Page count
                Figures: 5, Tables: 0, References: 21, Pages: 5
                Categories
                Deformity, Deformity
                Degenerative, Degenerative
                Spine, Spine
                Cervical, Cervical
                Thoracic, Thoracic
                Technique, Technique
                Surgical-Technique, Surgical Technique
                Case Lesson

                kyphoscoliosis,pedicle subtraction osteotomy,ankylosing spondylitis,global spine alignment,3co = three-column osteotomy,as = ankylosing spondylitis,cbva = chin-brow vertical angle,dar = deformity angular ratio,ll = lumbar lordosis,pi = pelvic incidence,pso = pedicle subtraction osteotomy,pt = pelvic tilt,ss = sacral slope,sva = sagittal vertical axis,t1s = t1 slope,tk = thoracic kyphosis,vcr = vertebral column resection

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