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      Calciphylaxis : Diagnosis, Pathogenesis, and Treatment

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      Journal: Advances in Skin & Wound Care
      Publisher: Ovid Technologies (Wolters Kluwer Health)

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          Abstract

          To provide information on the pathogenesis, clinical features, diagnosis, and treatment of calciphylaxis.

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          Calciphylaxis: risk factors, diagnosis, and treatment.

          Sagar Nigwekar, Daniela Kroshinsky, Rosalynn Nazarian … (2015)
          Calciphylaxis is a rare but devastating condition that has continued to challenge the medical community since its early descriptions in the scientific literature many decades ago. It is predominantly seen in patients with chronic kidney failure treated with dialysis (uremic calciphylaxis) but is also described in patients with earlier stages of chronic kidney disease and with normal kidney function. In this review, we discuss the available medical literature regarding risk factors, diagnosis, and treatment of both uremic and nonuremic calciphylaxis. High-quality evidence for the evaluation and management of calciphylaxis is lacking at this time due to its rare incidence and poorly understood pathogenesis and the relative paucity of collaborative research efforts. We hereby provide a summary of recommendations developed by a multidisciplinary team for patients with calciphylaxis.
          Article 0 comments Cited 135 times – based on 0 reviews     Review now
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            Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralization.

            Leon Schurgers, Jouni Uitto, Chris P M Reutelingsperger (2013)
            Vascular mineralization has recently emerged as a risk factor for cardiovascular morbidity and mortality. Previously regarded as a passive end-stage process, vascular mineralization is currently recognized as an actively regulated process with cellular and humoral contributions. The discovery that the vitamin K-dependent matrix Gla-protein (MGP) is a strong inhibitor of vascular calcification has propelled our mechanistic understanding of this process and opened novel avenues for diagnosis and treatment. This review focuses on molecular mechanisms of vascular mineralization involving MGP and discusses the potential for treatments and biomarkers to monitor patients at risk for vascular mineralization. Copyright © 2013 Elsevier Ltd. All rights reserved.
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              Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7.

              Leon Schurgers, Kirsten J F Teunissen, Karly Hamulyák … (2007)
              Vitamin K is a cofactor in the production of blood coagulation factors (in the liver), osteocalcin (in bone), and matrix Gla protein (cartilage and vessel wall). Accumulating evidence suggests that for optimal bone and vascular health, relatively high intakes of vitamin K are required. The synthetic short-chain vitamin K(1) is commonly used in food supplements, but recently the natural long-chain menaquinone-7 (MK-7) has also become available as an over-the-counter (OTC) supplement. The purpose of this paper was to compare in healthy volunteers the absorption and efficacy of K(1) and MK-7. Serum vitamin K species were used as a marker for absorption and osteocalcin carboxylation as a marker for activity. Both K(1) and MK-7 were absorbed well, with peak serum concentrations at 4 hours after intake. A major difference between the 2 vitamin K species is the very long half-life time of MK-7, resulting in much more stable serum levels, and accumulation of MK-7 to higher levels (7- to 8-fold) during prolonged intake. MK-7 induced more complete carboxylation of osteocalcin, and hematologists should be aware that preparations supplying 50 mug/d or more of MK-7 may interfere with oral anticoagulant treatment in a clinically relevant way.
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                Author and article information

                Journal
                Title: Advances in Skin & Wound Care
                Abbreviated Title: Advances in Skin & Wound Care
                Publisher: Ovid Technologies (Wolters Kluwer Health)
                ISSN (Print): 1527-7941
                Publication date Created: 2019
                Publication date (Print): May 2019
                Volume: 32
                Issue: 5
                Pages: 205-215
                Article
                DOI: 10.1097/01.ASW.0000554443.14002.13
                PubMed ID: 31008757
                SO-VID: 34e79b8b-a7d2-41b4-8a41-577da1a1a66d
                Copyright © © 2019
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