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      Bioluminescence-Driven Optogenetics

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          Abstract

          Bioluminescence-based technologies are among the most commonly used methods to quantify and visualise physiology at the cellular and organismal levels. However, the potential of bioluminescence beyond reporter technologies remains largely unexplored. Here, we provide an overview of the emerging approaches employing bioluminescence as a biological light source that triggers physiological events and controls cell behaviour and discuss its possible future application in synthetic biology.

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          Optogenetics.

          Karl Deisseroth (2011)
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            Optogenetics in neural systems.

            Ofer Yizhar, Lief Fenno, Murtaza Mogri … (2011)
            Both observational and perturbational technologies are essential for advancing the understanding of brain function and dysfunction. But while observational techniques have greatly advanced in the last century, techniques for perturbation that are matched to the speed and heterogeneity of neural systems have lagged behind. The technology of optogenetics represents a step toward addressing this disparity. Reliable and targetable single-component tools (which encompass both light sensation and effector function within a single protein) have enabled versatile new classes of investigation in the study of neural systems. Here we provide a primer on the application of optogenetics in neuroscience, focusing on the single-component tools and highlighting important problems, challenges, and technical considerations. Copyright © 2011 Elsevier Inc. All rights reserved.
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              The development and application of optogenetics.

              Lief Fenno, Ofer Yizhar, Karl Deisseroth (2011)
              Genetically encoded, single-component optogenetic tools have made a significant impact on neuroscience, enabling specific modulation of selected cells within complex neural tissues. As the optogenetic toolbox contents grow and diversify, the opportunities for neuroscience continue to grow. In this review, we outline the development of currently available single-component optogenetic tools and summarize the application of various optogenetic tools in diverse model organisms.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Life (Basel)
                Journal ID (iso-abbrev): Life (Basel)
                Journal ID (publisher-id): life
                Title: Life
                Publisher: MDPI
                ISSN (Electronic): 2075-1729
                Publication date (Electronic): 28 November 2020
                Publication date Collection: December 2020
                Volume: 10
                Issue: 12
                Electronic Location Identifier: 318
                Affiliations
                [1 ]Synthetic Biology Group, MRC London Institute of Medical Sciences, London W12 0NN, UK; m.sureda-vives17@ 123456imperial.ac.uk
                [2 ]Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London W12 0NN, UK
                [3 ]Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russia
                Author notes
                Author information
                https://orcid.org/0000-0002-5375-6341
                Article
                Publisher ID: life-10-00318
                DOI: 10.3390/life10120318
                PMC ID: 7760859
                PubMed ID: 33260589
                SO-VID: 33b7239a-1aec-4e31-9139-c5c289d07051
                Copyright © © 2020 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 09 November 2020
                Date accepted : 25 November 2020
                Categories
                Subject: Review

                Keywords: bioluminescence,optogenetics,bret,synthetic biology,luciferase,luciferin,luminopsin,photosensitiser,light-based communication
                Data availability:
                Keywords: bioluminescence, optogenetics, bret, synthetic biology, luciferase, luciferin, luminopsin, photosensitiser, light-based communication

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