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      Constrained polarization evolution simplifies depth-resolved retardation measurements with polarization-sensitive optical coherence tomography

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          Abstract

          We observed that the polarization state of light after round-trip propagation through a birefringent medium frequently aligns with the employed input polarization state ‘mirrored’ by the horizontal plane of the Poincaré sphere. We explored the predisposition for this mirror state and evidence that it constrains the evolution of polarization states as a function of the round-trip depth into weakly scattering birefringent samples, as measured with polarization-sensitive optical coherence tomography (PS-OCT). Combined with spectral variations in the polarization state transmitted through system components, we demonstrate how this constraint enables measurement of depth-resolved birefringence using only a single input polarization state, which offers a critical simplification compared to conventional PS-OCT employing two input states.

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          Author and article information

          Journal
          Biomed Opt Express
          Biomed Opt Express
          BOE
          Biomedical Optics Express
          Optical Society of America
          2156-7085
          17 September 2019
          01 October 2019
          : 10
          : 10
          : 5207-5222
          Affiliations
          [1 ]School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore, 639798, Singapore
          [2 ]School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, 637459, Singapore
          [3 ]Singapore Eye Research Institute, Singapore, 169856, Singapore
          [4 ]Harvard Medical School and Massachusetts General Hospital, Wellman Center for Photomedicine, Boston, Massachusetts 02114, USA
          [5 ]Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
          [6 ]These authors contributed equally
          [7 ]These authors contributed equally
          [8 ]Corresponding author: LIULINBO@ 123456ntu.edu.sg
          [9 ]Corresponding author: MVILLIGER@ 123456mgh.harvard.edu
          Author information
          https://orcid.org/0000-0001-9567-5059
          https://orcid.org/0000-0002-4683-9130
          https://orcid.org/0000-0001-6691-9253
          https://orcid.org/0000-0003-3819-1271
          Article
          PMC6788597 PMC6788597 6788597 372371
          10.1364/BOE.10.005207
          6788597
          31646042
          339bf5aa-5e35-45f1-bc99-6a243794d889
          © 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

          © 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

          History
          : 15 July 2019
          : 28 August 2019
          : 31 August 2019
          Funding
          Funded by: National Research Foundation Singapore 10.13039/501100001381
          Award ID: NRF-CRP13-2014-05
          Funded by: Ministry of Education - Singapore 10.13039/501100001459
          Award ID: 2018-T1-001-144
          Funded by: Agency for Science, Technology and Research 10.13039/501100001348
          Award ID: H17/01/a0/008
          Funded by: National Institutes of Health 10.13039/100000002
          Award ID: P41EB-015903
          Award ID: R03EB-024803
          Funded by: Terumo Corporation 10.13039/100000002
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