Inviting an author to review:
Find an author and click ‘Invite to review selected article’ near their name.
Search for authorsSearch for similar articles
3
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Anesthetic potential of essential oils from Brazilian native plants in Rhamdia quelen juveniles (silver catfish)

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Abstract The sedative and anesthetic actions of several essential oils (EO) on fish have been demonstrated, stimulating the search for new options for natural anesthetics. This work evaluated the safety and sedative and anesthetic efficacy of EOs from three native Brazilian plants, Acmella oleracea (jambu), Aloysia hatschbachii and Cordia verbenacea (whale herb) in juvenile Rhamdia quelen (silver catfish). Anesthetic induction and recovery protocols (20 to 400 mg L-1) and long exposure (48 h) from 10 to 100 mg L-1 were tested. The EOs performed sedative and/or anesthetic activities: AOOi at a concentration of 20 mg L-1, AOOl at 50 and 100 mg L-1, AHOl, and CVOL (only sedation) 50 mg L⁻¹, as there were no important adverse effects and/or mortality. The results obtained indicate that Cordia verbenacea EO is the most promising as a sedative for juvenile silver catfish at a concentration of 50 mg L⁻¹.

          Translated abstract

          Resumo As ações sedativas e anestésicas de diversos óleos essenciais (OE) em peixes têm sido demonstradas, estimulando a busca por novas opções de anestésicos naturais. Este trabalho avaliou a segurança e a eficácia sedativa e anestésica de OE de três plantas nativas brasileiras, Acmella oleracea (jambu), Aloysia hatschbachii e Cordia verbenacea (erva-baleeira) em juvenis de Rhamdia quelen (jundiá). Foram testados protocolos de indução e recuperação anestésica (20 a 400 mg L-1) e longa exposição (48 h) de 10 a 100 mg L-1. Os OEs realizavam atividades sedativas e/ou anestésicas: AOOi na concentração de 20 mg L-1, AOOl na concentração de 50 e 100 mg L-1, AHOl, e CVOL (somente sedação) 50 mg L-1 o AHOl (sedação e anestesia) e CVOL (sedação) na concentração de 50 mg L⁻¹, pois não houve efeitos adversos importantes e/ou mortalidade. Os resultados obtidos indicam que o OE de Cordia verbenacea é o mais promissor como sedativo para juvenis de jundiá na concentração de 50 mg L⁻¹.

          Related collections

          Most cited references93

          • Record: found
          • Abstract: not found
          • Article: not found

          Factors affecting secondary metabolite production in plants: volatile components and essential oils

            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Complex Interactions between Phytochemicals. The Multi-Target Therapeutic Concept of Phytotherapy

            Drugs derived from natural resources represent a significant segment of the pharmaceutical market as compared to randomly synthesized compounds. It is a goal of drug development programs to design selective ligands that act on single disease targets to obtain highly effective and safe drugs with low side effects. Although this strategy was successful for many new therapies, there is a marked decline in the number of new drugs introduced into clinical practice over the past decades. One reason for this failure may be due to the fact that the pathogenesis of many diseases is rather multi-factorial in nature and not due to a single cause. Phytotherapy, whose therapeutic efficacy is based on the combined action of a mixture of constituents, offers new treatment opportunities. Because of their biological defence function, plant secondary metabolites act by targeting and disrupting the cell membrane, by binding and inhibiting specific proteins or they adhere to or intercalate into RNA or DNA. Phytotherapeutics may exhibit pharmacological effects by the synergistic or antagonistic interaction of many phytochemicals. Mechanistic reasons for interactions are bioavailability, interference with cellular transport processes, activation of pro-drugs or deactivation of active compounds to inactive metabolites, action of synergistic partners at different points of the same signalling cascade (multi-target effects) or inhibition of binding to target proteins. "-Omics" technologies and systems biology may facilitate unravelling synergistic effects of herbal mixtures.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Anaesthesia of farmed fish: implications for welfare.

              During their life cycle as farmed animals, there are several situations in which fish are subjected to handling and confinement. Netting, weighing, sorting, vaccination, transport and, at the end, slaughter are frequent events under farming conditions. As research subjects, fish may also undergo surgical procedures that range from tagging, sampling and small incisions to invasive procedures. In these situations, treatment with anaesthetic agents may be necessary in order to ensure the welfare of the fish. The main objective of this paper is to review our knowledge of the effects of anaesthetic agents in farmed fish and their possible implications for welfare. As wide variations in response to anaesthesia have been observed both between and within species, special attention has been paid to the importance of secondary factors such as body weight, water temperature and acute stress. In this review, we have limited ourselves to the anaesthetic agents such as benzocaine, metacaine (MS-222), metomidate hydrochloride, isoeugenol, 2-phenoxyethanol and quinaldine. Anaesthetic protocols of fish usually refer to one single agent, whereas protocols of human and veterinary medicine cover combinations of several drugs, each contributing to the effects needed in the anaesthesia. As stress prior to anaesthesia may result in abnormal reactions, pre-anaesthetic sedation is regularly used in order to reduce or avoid stress and is an integral part of the veterinary protocols of higher vertebrates. Furthermore, the anaesthetic agents that are used in order to obtain general anaesthesia are combined with analgesic agents that target nociception. The increased use of such combinations in fish is therefore included as a special section. Anaesthetic agents are widely used to avoid stress during various farming procedures. While several studies report that anaesthetics are effective in reducing the stress associated with confinement and handling, there are indications that anaesthesia may in itself induce a stress response, measured by elevated levels of cortisol. MS-222 has been reported to elicit high cortisol release rates immediately following exposure, while benzocaine causes a bimodal response. Metomidate has an inhibitory effect on cortisol in fish and seems to induce the lowest release of cortisol of the agents reported in the literature. Compared to what is observed following severe stressors such as handling and confinement, the amount of cortisol released in response to anaesthesia appears to be low but may represent an extra load under otherwise stressful circumstances. Furthermore, anaesthetics may cause secondary adverse reactions such as acidosis and osmotic stress due to respiratory arrest and insufficient exchange of gas and ions between the blood and the water. All in all, anaesthetics may reduce stress and thereby improve welfare but can also have unwanted side effects that reduce the welfare of the fish and should therefore always be used with caution. Finally, on the basis of the data reported in the literature and our own experience, we recommend that anaesthetic protocols should always be tested on a few fish under prevailing conditions in order to ensure an adequate depth of anaesthesia. This recommendation applies whether a single agent or a combination of agents is used, although it appears that protocols comprising combinations of agents provide wider safety margins. The analgesic effects of currently used agents, in spite of their proven local effects, are currently being debated as the agents are administrated to fish via inhalation rather than locally at the target site. We therefore recommend that all protocols of procedures requiring general anaesthesia should be complemented by administration of agents with analgesic effect at the site of tissue trauma.
                Bookmark

                Author and article information

                Journal
                ni
                Neotropical Ichthyology
                Neotrop. ichthyol.
                Sociedade Brasileira de Ictiologia (Maringá, PR, Brazil )
                1679-6225
                1982-0224
                2024
                : 22
                : 3
                : e240034
                Affiliations
                [1] Santa Maria Rio Grande do Sul orgnameUniversidade Federal de Santa Maria orgdiv1Programa de Pós-Graduação em Farmacologia Brazil medvet.chmf@ 123456gmail.com
                [2] Santa Maria Rio Grande do Sul orgnameUniversidade Federal de Santa Maria orgdiv1Laboratório de Extrativos Vegetais Brazil fabi.ferrari06@ 123456gmail.com
                [3] Santa Maria Rio Grande do Sul orgnameUniversidade Federal de Santa Maria orgdiv1Departamento de Fisiologia e Farmacologia Brazil
                [4] Frederico Westphalen Rio Grande do Sul orgnameUniversidade Federal de Santa Maria orgdiv1Departamento de Engenharia Agronômica e Ambiental Brazil denise@ 123456ufsm.br
                [5] Santa Maria Rio Grande do Sul orgnameUniversidade Federal de Santa Maria orgdiv1Departamento de Ciências Florestais Brazil fjsutili@ 123456gmail.com
                [6] Santa Maria Rio Grande do Sul orgnameUniversidade Federal de Santa Maria orgdiv1Departamento de Farmácia Industrial Brazil
                Author information
                https://orcid.org/0000-0001-7111-2235
                https://orcid.org/0009-0005-2815-5930
                https://orcid.org/0000-0002-8770-0100
                https://orcid.org/0000-0002-9963-4956
                https://orcid.org/0000-0002-0639-7411
                https://orcid.org/0000-0002-6509-949X
                Article
                S1679-62252024000300207 S1679-6225(24)02200300207
                10.1590/1982-0224-2024-0034
                332f0f86-a635-429d-b75b-264a51a3f42e

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                : 17 April 2024
                : 29 July 2024
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 93, Pages: 0
                Product

                SciELO Brazil

                Categories
                Original Article

                Cordia verbenacea,Acmella oleracea,Aloysia hatschbachii,Anesthesia,Sedation,Anestesia,Sedação

                Comments

                Comment on this article

                scite_
                0
                0
                0
                0
                Smart Citations
                0
                0
                0
                0
                Citing PublicationsSupportingMentioningContrasting
                View Citations

                See how this article has been cited at scite.ai

                scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

                Similar content748

                Most referenced authors973