The pruritus- and TH2-associated cytokine IL-31 promotes growth of sensory nerves.

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Abstract

Pruritus is a cardinal symptom of atopic dermatitis, and an increased cutaneous sensory network is thought to contribute to pruritus. Although the immune cell-IL-31-neuron axis has been implicated in severe pruritus during atopic skin inflammation, IL-31's neuropoietic potential remains elusive.

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Journal ID (iso-abbrev): J. Allergy Clin. Immunol.

Title: The Journal of allergy and clinical immunology

ISSN (Electronic): 1097-6825

ISSN (Print): 0091-6749

Publication date (Electronic): Aug 2016

Volume: 138

Issue: 2

Affiliations

[1 ] Department of Dermatology, University Hospital Düsseldorf, Düsseldorf, Germany.

[2 ] ZymoGenetics (a Bristol-Myers Squibb Company), Seattle, Wash.

[3 ] Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.

[4 ] Department of Informatics, King's College London, London, United Kingdom.

[5 ] Physiology and Biophysics, University of California, Irvine, Calif.

[6 ] Department of Neurophysiology, Heinrich Heine University, Düsseldorf, Germany.

[7 ] Molecular Neurobiology Laboratory, Neurology, Heinrich Heine University, Düsseldorf, Germany.

[8 ] Department of Dermatology, University Hospital Düsseldorf, Düsseldorf, Germany; Department of Dermatology and UCD Charles Institute for Translational Dermatology, Dublin, Ireland.

[9 ] Department of Dermatology, University Hospital Düsseldorf, Düsseldorf, Germany. Electronic address: bernhard.homey@uni-duesseldorf.de.

Article

Publisher Item ID: S0091-6749(16)30005-7

DOI: 10.1016/j.jaci.2016.02.020

PubMed ID: 27212086

SO-VID: 32e2bd5e-83c3-4cfa-893f-ebe63b149db2

History

Keywords: IL-31,IL-31 receptor α,atopic dermatitis,cutaneous hyperinnervation,dorsal root ganglia,nerve growth

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Keywords: IL-31, IL-31 receptor α, atopic dermatitis, cutaneous hyperinnervation, dorsal root ganglia, nerve growth

The pruritus- and TH2-associated cytokine IL-31 promotes growth of sensory nerves.

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Karger: Dermatology

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