Tripodal squaramide conjugates as highly effective transmembrane anion transporters.

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Abstract

Two tripodal squaramide conjugates having 4-(trifluoromethyl)phenyl and 3,5-bis(trifluoromethyl)phenyl substituents were synthesized and found to exhibit highly efficient transmembrane anion transport with the EC50 values being 0.14 and 0.75mol%, respectively. Though one of them has been reported to act as a strong anion receptor, in particular for sulfate anions, these two compounds exhibit no significant selectivity with respect to the tested monovalent anions and a very low level of activity in the presence of sulfate anions.

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Journal

Journal ID (iso-abbrev): Bioorg. Med. Chem. Lett.

Title: Bioorganic & medicinal chemistry letters

Publisher: Elsevier BV

ISSN (Electronic): 1464-3405

ISSN (Print): 0960-894X

Publication date (Electronic): May 01 2017

Volume: 27

Issue: 9

Affiliations

[1 ] Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China.

[2 ] Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China. Electronic address: whchen@smu.edu.cn.

Article

Publisher Item ID: S0960-894X(17)30250-0

DOI: 10.1016/j.bmcl.2017.03.024

PubMed ID: 28325602

SO-VID: 32aaa89b-7889-49ed-8579-bb0ea09a0e7f

History

Keywords: Anionophore,Anionophoric activity,Ion selectivity,Squaramide

Data availability:

Keywords: Anionophore, Anionophoric activity, Ion selectivity, Squaramide

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