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      Effectiveness of a Transdiagnostic Guided Internet-Delivered Protocol for Emotional Disorders Versus Treatment as Usual in Specialized Care: Randomized Controlled Trial

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          Abstract

          Background

          Anxiety disorders and depression (emotional disorders) are highly prevalent mental disorders. Extensive empirical evidence supports the efficacy of cognitive behavioral therapy (CBT) for the treatment of these disorders. However, there are still some barriers related to their dissemination and implementation, which make it difficult for patients to receive these treatments, especially in public health care settings where resources are limited. Recent advances in improving CBT dissemination encompass different perspectives. One is the transdiagnostic approach, which offers treatment protocols that can be used for a range of emotional disorders. Another approach is the use of the internet to reach a larger number of people who could benefit from CBT.

          Objective

          This study aimed to analyze the effectiveness and acceptability of a transdiagnostic internet-delivered protocol (EmotionRegulation) with human and automated guidance in patients from public specialized mental health care settings.

          Methods

          A 2-armed randomized controlled trial (RCT) was conducted to compare the effectiveness of EmotionRegulation with treatment as usual (TAU) in specialized mental health care. In all, 214 participants were randomly assigned to receive either EmotionRegulation (n=106) or TAU (n=108). Measurement assessments were conducted at pre- and postintervention and at a 3-month follow-up.

          Results

          The results revealed the superiority of EmotionRegulation over TAU on measures of depression ( d=0.41), anxiety ( d=0.35), and health-related quality of life ( d=−0.45) at posttreatment, and these gains were maintained at the 3-month follow-up. Furthermore, the results for expectations and opinions showed that EmotionRegulation was well accepted by participants.

          Conclusions

          EmotionRegulation was more effective than TAU for the treatment of emotional disorders in the Spanish public mental health system. The implications of this RCT, limitations, and suggestions for future research are discussed.

          Trial Registration

          ClinicalTrials.gov NCT02345668; https://clinicaltrials.gov/ct2/show/NCT02345668

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          Most cited references76

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          Use of mental health services for anxiety, mood, and substance disorders in 17 countries in the WHO world mental health surveys.

          Mental disorders are major causes of disability worldwide, including in the low-income and middle-income countries least able to bear such burdens. We describe mental health care in 17 countries participating in the WHO world mental health (WMH) survey initiative and examine unmet needs for treatment. Face-to-face household surveys were undertaken with 84,850 community adult respondents in low-income or middle-income (Colombia, Lebanon, Mexico, Nigeria, China, South Africa, Ukraine) and high-income countries (Belgium, France, Germany, Israel, Italy, Japan, Netherlands, New Zealand, Spain, USA). Prevalence and severity of mental disorders over 12 months, and mental health service use, were assessed with the WMH composite international diagnostic interview. Logistic regression analysis was used to study sociodemographic predictors of receiving any 12-month services. The number of respondents using any 12-month mental health services (57 [2%; Nigeria] to 1477 [18%; USA]) was generally lower in developing than in developed countries, and the proportion receiving services tended to correspond to countries' percentages of gross domestic product spent on health care. Although seriousness of disorder was related to service use, only five (11%; China) to 46 (61%; Belgium) of patients with severe disorders received any care in the previous year. General medical sectors were the largest sources of mental health services. For respondents initiating treatments, 152 (70%; Germany) to 129 (95%; Italy) received any follow-up care, and one (10%; Nigeria) to 113 (42%; France) received treatments meeting minimum standards for adequacy. Patients who were male, married, less-educated, and at the extremes of age or income were treated less. Unmet needs for mental health treatment are pervasive and especially concerning in less-developed countries. Alleviation of these unmet needs will require expansion and optimum allocation of treatment resources.
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            Advantages and limitations of Internet-based interventions for common mental disorders.

            Several Internet interventions have been developed and tested for common mental disorders, and the evidence to date shows that these treatments often result in similar outcomes as in face-to-face psychotherapy and that they are cost-effective. In this paper, we first review the pros and cons of how participants in Internet treatment trials have been recruited. We then comment on the assessment procedures often involved in Internet interventions and conclude that, while online questionnaires yield robust results, diagnoses cannot be determined without any contact with the patient. We then review the role of the therapist and conclude that, although treatments including guidance seem to lead to better outcomes than unguided treatments, this guidance can be mainly practical and supportive rather than explicitly therapeutic in orientation. Then we briefly describe the advantages and disadvantages of treatments for mood and anxiety disorders and comment on ways to handle comorbidity often associated with these disorders. Finally we discuss challenges when disseminating Internet interventions. In conclusion, there is now a large body of evidence suggesting that Internet interventions work. Several research questions remain open, including how Internet interventions can be blended with traditional forms of care. Copyright © 2014 World Psychiatric Association.
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              Credibility of analogue therapy rationales

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                Author and article information

                Contributors
                Journal
                J Med Internet Res
                J. Med. Internet Res
                JMIR
                Journal of Medical Internet Research
                JMIR Publications (Toronto, Canada )
                1439-4456
                1438-8871
                July 2020
                7 July 2020
                : 22
                : 7
                : e18220
                Affiliations
                [1 ] Department of Basic and Clinical Psychology, and Psychobiology Universitat Jaume I Castellón de la Plana Spain
                [2 ] CIBER Fisiopatología Obesidad y Nutrición (CIBERObn) Instituto Carlos III Madrid Spain
                [3 ] Department of Personality, Assessment, and Clinical Psychology Universidad Complutense de Madrid Madrid Spain
                [4 ] Department of Psychiatry Hospital Universitari Vall d'Hebron Barcelona Spain
                [5 ] Group of Psychiatry, Mental Health and Addictions, Vall d'Hebron Research Institute (VHIR) Barcelona Spain
                [6 ] Biomedical Network Research Centre on Mental Health (CIBERSAM) Barcelona Spain
                [7 ] Department of Psychiatry and Forensic Medicine Universitat Autònoma de Barcelona Barcelona Spain
                Author notes
                Corresponding Author: Alberto González-Robles vrobles@ 123456uji.es
                Author information
                https://orcid.org/0000-0002-3749-3756
                https://orcid.org/0000-0003-4398-4014
                https://orcid.org/0000-0001-9250-8714
                https://orcid.org/0000-0001-9815-4902
                https://orcid.org/0000-0003-1622-0350
                https://orcid.org/0000-0001-8783-6959
                Article
                v22i7e18220
                10.2196/18220
                7381075
                32673226
                32a3d539-b388-47a5-a5bf-9c0ba43edca0
                ©Alberto González-Robles, Amanda Díaz-García, Azucena García-Palacios, Pablo Roca, Josep Antoni Ramos-Quiroga, Cristina Botella. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 07.07.2020.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on http://www.jmir.org/, as well as this copyright and license information must be included.

                History
                : 14 February 2020
                : 24 March 2020
                : 8 April 2020
                : 8 April 2020
                Categories
                Original Paper
                Original Paper

                Medicine
                transdiagnostic,internet,cognitive behavioral therapy,emotional disorders,depression,anxiety,specialized care

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