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Coronary Computed Tomography Angiography From Clinical Uses to Emerging Technologies
Khaled M. Abdelrahman ,
Marcus Y. Chen ,
Amit K. Dey ,
Renu Virmani ,
Aloke V. Finn ,
Ramzi Y. Khamis ,
Andrew D. Choi ,
James K. Min ,
Michelle C. Williams ,
Andrew J. Buckler ,
Charles A. Taylor ,
Campbell Rogers ,
Habib Samady ,
Charalambos Antoniades ,
Leslee J. Shaw ,
Matthew J. Budoff ,
Udo Hoffmann ,
Ron Blankstein ,
Jagat Narula ,
Nehal N. Mehta
September 2020
September 2020
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Abstract
Evaluation of coronary artery disease (CAD) using coronary computed tomography angiography
(CCTA) has seen a paradigm shift in the last decade. Evidence increasingly supports
the clinical utility of CCTA across various stages of CAD, from the detection of early
subclinical disease to the assessment of acute chest pain. Additionally, CCTA can
be used to noninvasively quantify plaque burden and identify high-risk plaque, aiding
in diagnosis, prognosis, and treatment. This is especially important in the evaluation
of CAD in immune-driven conditions with increased cardiovascular disease prevalence.
Emerging applications of CCTA based on hemodynamic indices and plaque characterization
may provide personalized risk assessment, affect disease detection, and further guide
therapy. This review provides an update on the evidence, clinical applications, and
emerging technologies surrounding CCTA as highlighted at the 2019 National Heart,
Lung and Blood Institute CCTA Summit.