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      A study on the fabrication of metal microneedle array electrodes for ECG detection based on low melting point Bi–In–Sn alloys

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          Abstract

          This study describes the fabrication and characteristics of microneedle array electrodes (MAEs) using Bismuth–Indium–Tin (Bi–In–Sn) alloys. The MAEs consist of 57 pyramid-shaped needles measuring 340 μm wide and 800 μm high. The fabrication process involved micromolding the alloys in a vacuum environment. Physical tests demonstrated that Bi–In–Sn MAEs have good mechanical strength, indicating their suitability for successful skin penetration. The electrode–skin interface impedance test confirmed that Bi–In–Sn MAEs successfully penetrated the skin. Impedance measurements revealed the importance of insulating the microneedle electrodes for optimal electrical performance, and a UV-curable Polyurethane Acrylate coating was applied to enhance insulation. Electrocardiogram measurements using the Bi–In–Sn MAEs demonstrated performance comparable to that of traditional Ag/AgCl electrodes, which shows promise for accurate data collection. Overall, the study demonstrates successful, minimally-invasive skin insertion, improved electrical insulation, and potential applications of Bi–In–Sn microneedle array. These findings contribute to advancements in microneedle technology for biomedical applications.

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          Dissolving microneedles for transdermal drug delivery.

          Microfabrication technology has been adapted to produce micron-scale needles as a safer and painless alternative to hypodermic needle injection, especially for protein biotherapeutics and vaccines. This study presents a design that encapsulates molecules within microneedles that dissolve within the skin for bolus or sustained delivery and leave behind no biohazardous sharp medical waste. A fabrication process was developed based on casting a viscous aqueous solution during centrifugation to fill a micro-fabricated mold with biocompatible carboxymethylcellulose or amylopectin formulations. This process encapsulated sulforhodamine B, bovine serum albumin, and lysozyme; lysozyme was shown to retain full enzymatic activity after encapsulation and to remain 96% active after storage for 2 months at room temperature. Microneedles were also shown to be strong enough to insert into cadaver skin and then to dissolve within minutes. Bolus delivery was achieved by encapsulating molecules just within microneedle shafts. For the first time, sustained delivery over hours to days was achieved by encapsulating molecules within the microneedle backing, which served as a controlled release reservoir that delivered molecules by a combination of swelling the backing with interstitial fluid drawn out of the skin and molecule diffusion into the skin via channels formed by dissolved microneedles. We conclude that dissolving microneedles can be designed to gently encapsulate molecules, insert into skin, and enable bolus or sustained release delivery.
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            ECG analysis: a new approach in human identification

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              A survey on ECG analysis

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                Author and article information

                Contributors
                pa90201@gachon.ac.kr
                soonmseo@gachon.ac.kr
                Journal
                Sci Rep
                Sci Rep
                Scientific Reports
                Nature Publishing Group UK (London )
                2045-2322
                21 December 2023
                21 December 2023
                2023
                : 13
                : 22931
                Affiliations
                [1 ]Department of BioNano Technology, Gachon University, ( https://ror.org/03ryywt80) Seongnam-Si, Gyeonggi-Do 13120 Republic of Korea
                [2 ]Department of Electronic Engineering, Gachon University, ( https://ror.org/03ryywt80) Seongnam-Si, Gyeonggi-Do 13120 Republic of Korea
                [3 ]Department of Life Science, Gachon University, ( https://ror.org/03ryywt80) Seongnam-Si, Gyeonggi-Do 13120 Republic of Korea
                Article
                50472
                10.1038/s41598-023-50472-y
                10739879
                38129504
                32898204-81da-441b-b57a-12682c921e4f
                © The Author(s) 2023

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 30 July 2023
                : 20 December 2023
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                © Springer Nature Limited 2023

                Uncategorized
                biomedical engineering,metals and alloys
                Uncategorized
                biomedical engineering, metals and alloys

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