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      Rehabilitation of Executive Functioning in Patients with Frontal Lobe Brain Damage with Goal Management Training

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          Abstract

          Executive functioning deficits due to brain disease affecting frontal lobe functions cause significant real-life disability, yet solid evidence in support of executive functioning interventions is lacking. Goal Management Training (GMT), an executive functioning intervention that draws upon theories concerning goal processing and sustained attention, has received empirical support in studies of patients with traumatic brain injury, normal aging, and case studies. GMT promotes a mindful approach to complex real-life tasks that pose problems for patients with executive functioning deficits, with a main goal of periodically stopping ongoing behavior to monitor and adjust goals. In this controlled trial, an expanded version of GMT was compared to an alternative intervention, Brain Health Workshop that was matched to GMT on non-specific characteristics that can affect intervention outcome. Participants included 19 individuals in the chronic phase of recovery from brain disease (predominantly stroke) affecting frontal lobe function. Outcome data indicated specific effects of GMT on the Sustained Attention to Response Task as well as the Tower Test, a visuospatial problem-solving measure that reflected far transfer of training effects. There were no significant effects on self-report questionnaires, likely owing to the complexity of these measures in this heterogeneous patient sample. Overall, these data support the efficacy of GMT in the rehabilitation of executive functioning deficits.

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          Most cited references25

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          The attention system of the human brain.

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            Specific impairments of planning.

            T Shallice (1982)
            An information-processing model is outlined that predicts that performance on non-routine tasks can be impaired independently of performance on routine tasks. The model is related to views on frontal lobe functions, particularly those of Luria. Two methods of obtaining more rigorous tests of the model are discussed. One makes use of ideas from artificial intelligence to derive a task heavily loaded on planning abilities. A group of patients with left anterior lesions has a specific deficit on the task. Subsidiary investigations support the inference that this is a planning impairment.
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              'Oops!': performance correlates of everyday attentional failures in traumatic brain injured and normal subjects.

              Insufficient attention to tasks can result in slips of action as automatic, unintended action sequences are triggered inappropriately. Such slips arise in part from deficits in sustained attention, which are particularly likely to happen following frontal lobe and white matter damage in traumatic brain injury (TBI). We present a reliable laboratory paradigm that elicits such slips of action and demonstrates high correlations between the severity of brain damage and relative-reported everyday attention failures in a group of 34 TBI patients. We also demonstrate significant correlations between self- and informant-reported everyday attentional failures and performance on this paradigm in a group of 75 normal controls. The paradigm (the Sustained Attention to Response Task-SART) involves the withholding of key presses to rare (one in nine) targets. Performance on the SART correlates significantly with performance on tests of sustained attention, but not other types of attention, supporting the view that this is indeed a measure of sustained attention. We also show that errors (false presses) on the SART can be predicted by a significant shortening of reaction times in the immediately preceding responses, supporting the view that these errors are a result of 'drift' of controlled processing into automatic responding consequent on impaired sustained attention to task. We also report a highly significant correlation of -0.58 between SART performance and Glasgow Coma Scale Scores in the TBI group.
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                Author and article information

                Journal
                Front Hum Neurosci
                Front. Hum. Neurosci.
                Frontiers in Human Neuroscience
                Frontiers Research Foundation
                1662-5161
                17 February 2011
                2011
                : 5
                : 9
                Affiliations
                [1] 1simpleRotman Research Institute, Baycrest Centre Toronto, ON, Canada
                [2] 2simpleDepartment of Psychology, University of Toronto Toronto, ON, Canada
                [3] 3simpleDepartment of Medicine (Neurology), University of Toronto Toronto, ON, Canada
                [4] 4simpleDepartment of Medicine (Neurosurgery), University of Toronto Toronto, ON, Canada
                [5] 5simpleKeenan Research Centre of the Li Ka Shing Knowledge Institute at St. Michael's Hospital Toronto, ON, Canada
                [6] 6simpleDepartment of Occupational and Rehabilitation Sciences, University of Toronto Toronto, ON, Canada
                [7] 7simpleHeart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre Toronto, ON, Canada
                [8] 8simpleMedical Research Council Cognition and Brain Sciences Unit Cambridge, England
                [9] 9simpleDepartment of Psychology and Neurosciences Trinity College, Dublin, Ireland
                Author notes

                Edited by: Donald T. Stuss, Baycrest Centre for Geriatric Care, Canada

                Reviewed by: Gail A. Eskes, Dalhousie University, Canada; James F. Malec, Rehabilitation Hospital of Indiana, USA

                *Correspondence: Brian Levine, Rotman Research Institute, Baycrest Centre, 3560 Bathurst Street, Toronto, ON, Canada M6A 2E1. e-mail: blevine@ 123456rotman-baycrest.on.ca
                Article
                10.3389/fnhum.2011.00009
                3043269
                21369362
                32223b87-d287-4807-a69f-b4a0597ae2e2
                Copyright © 2011 Levine, Schweizer, O'Connor, Turner, Gillingham, Stuss, Manly and Robertson.

                This is an open-access article subject to an exclusive license agreement between the authors and Frontiers Media SA, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.

                History
                : 22 September 2010
                : 11 January 2011
                Page count
                Figures: 1, Tables: 3, Equations: 0, References: 45, Pages: 9, Words: 7452
                Categories
                Neuroscience
                Original Research

                Neurosciences
                rehabilitation,executive functioning,frontal lobe,stroke,traumatic brain injury mindfulness

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