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      A Narrative-Gamified Mental Health App (Kuamsha) for Adolescents in Uganda: Mixed Methods Feasibility and Acceptability Study

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          Abstract

          Background

          Many adolescents in Uganda are affected by common mental disorders, but only a few affordable treatment options are available. Digital mental health interventions offer promising opportunities to reduce these large treatment gaps, but interventions specifically tailored for Ugandan adolescents are limited.

          Objective

          This study aimed to determine the feasibility and acceptability of the Kuamsha program, an intervention delivered through a gamified app with low-intensity telephonic guidance, as a way to promote mental health among adolescents from the general population in Uganda.

          Methods

          A 3-month pre-post single-arm trial was conducted with adolescents aged between 15 and 19 years living in Wakiso District, Central Uganda. The intervention was coproduced with adolescents from the study site to ensure that it was culturally acceptable. The feasibility and acceptability of the intervention were evaluated using an explanatory sequential mixed methods approach. Feasibility was assessed by collecting data on trial retention rates and treatment adherence rates. Acceptability was assessed through a questionnaire and in-depth interviews with participants following the conclusion of the intervention period. As a secondary objective, we explored the changes in participants’ mental health before and after the intervention.

          Results

          A total of 31 adolescents were recruited for the study. Results from the study showed high levels of feasibility and acceptability. Trial retention rates exceeded 90%, and treatment adherence was ≥80%. These results, evaluated against our predefined trial progression criteria, indicate a successful feasibility study, with all criteria exceeding the thresholds necessary to progress to a larger trial. App engagement metrics, such as time spent on the app and modules completed, exceeded existing literature benchmarks, and many adolescents continued to use the app after the intervention. In-depth interviews and questionnaire responses revealed high acceptability levels. Depressive symptoms trended toward reduction (mean difference: 1.41, 95% CI –0.60 to 3.42, Cohen d=0.30), although this was not statistically significant ( P=.16). Supporting this trend, we also observed a reduction in the proportion of participants with moderate depressive symptoms from 32% (10/31) to 17% (5/29) after the intervention, but this change was also not significant ( P=.10).

          Conclusions

          This study presents evidence to support the Kuamsha program as a feasible and acceptable digital mental health program for adolescents in Uganda. A fully powered randomized controlled trial is needed to assess its effectiveness in improving adolescents’ mental health.

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          Most cited references65

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          Using thematic analysis in psychology

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            Generalized anxiety disorder (GAD) is one of the most common mental disorders; however, there is no brief clinical measure for assessing GAD. The objective of this study was to develop a brief self-report scale to identify probable cases of GAD and evaluate its reliability and validity. A criterion-standard study was performed in 15 primary care clinics in the United States from November 2004 through June 2005. Of a total of 2740 adult patients completing a study questionnaire, 965 patients had a telephone interview with a mental health professional within 1 week. For criterion and construct validity, GAD self-report scale diagnoses were compared with independent diagnoses made by mental health professionals; functional status measures; disability days; and health care use. A 7-item anxiety scale (GAD-7) had good reliability, as well as criterion, construct, factorial, and procedural validity. A cut point was identified that optimized sensitivity (89%) and specificity (82%). Increasing scores on the scale were strongly associated with multiple domains of functional impairment (all 6 Medical Outcomes Study Short-Form General Health Survey scales and disability days). Although GAD and depression symptoms frequently co-occurred, factor analysis confirmed them as distinct dimensions. Moreover, GAD and depression symptoms had differing but independent effects on functional impairment and disability. There was good agreement between self-report and interviewer-administered versions of the scale. The GAD-7 is a valid and efficient tool for screening for GAD and assessing its severity in clinical practice and research.
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              The PHQ-9: validity of a brief depression severity measure.

              While considerable attention has focused on improving the detection of depression, assessment of severity is also important in guiding treatment decisions. Therefore, we examined the validity of a brief, new measure of depression severity. The Patient Health Questionnaire (PHQ) is a self-administered version of the PRIME-MD diagnostic instrument for common mental disorders. The PHQ-9 is the depression module, which scores each of the 9 DSM-IV criteria as "0" (not at all) to "3" (nearly every day). The PHQ-9 was completed by 6,000 patients in 8 primary care clinics and 7 obstetrics-gynecology clinics. Construct validity was assessed using the 20-item Short-Form General Health Survey, self-reported sick days and clinic visits, and symptom-related difficulty. Criterion validity was assessed against an independent structured mental health professional (MHP) interview in a sample of 580 patients. As PHQ-9 depression severity increased, there was a substantial decrease in functional status on all 6 SF-20 subscales. Also, symptom-related difficulty, sick days, and health care utilization increased. Using the MHP reinterview as the criterion standard, a PHQ-9 score > or =10 had a sensitivity of 88% and a specificity of 88% for major depression. PHQ-9 scores of 5, 10, 15, and 20 represented mild, moderate, moderately severe, and severe depression, respectively. Results were similar in the primary care and obstetrics-gynecology samples. In addition to making criteria-based diagnoses of depressive disorders, the PHQ-9 is also a reliable and valid measure of depression severity. These characteristics plus its brevity make the PHQ-9 a useful clinical and research tool.
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                Author and article information

                Contributors
                Journal
                JMIR Serious Games
                JMIR Serious Games
                JSG
                JMIR Serious Games
                JMIR Publications (Toronto, Canada )
                2291-9279
                2024
                19 December 2024
                : 12
                : e59381
                Affiliations
                [1 ] Department of Global Health and Social Medicine Harvard Medical School Harvard University Boston, MA United States
                [2 ] Department of Psychiatry University of Oxford Oxford United Kingdom
                [3 ] MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) School of Public Health, Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa
                [4 ] BRAC Kampala Uganda
                [5 ] Mind Ease London United Kingdom
                [6 ] College of Health Sciences Makerere University Kampala Uganda
                [7 ] Mental Health Project Medical Research Council/Uganda Virus Research Institute (MRC/UVRI) Kampala Uganda
                [8 ] Centre for Community Based Research Human Sciences Research Council Pietermaritzburg South Africa
                [9 ] SAMRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, School of Clinical Medicine, Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa
                [10 ] Mood Disorders Centre Department of Psychology University of Exeter Exeter United Kingdom
                [11 ] Department of Psychology University of California, Los Angeles Los Angeles, CA United States
                [12 ] Department of Psychiatry and Biobehavioral Sciences University of California, Los Angeles Los Angeles, CA United States
                [13 ] See Acknowledgments Oxford United Kingdom
                [14 ] BRAC University Kampala Uganda
                [15 ] Africa Health Research Institute KwaZulu Natal South Africa
                [16 ] Blavatnik School of Government University of Oxford Oxford United Kingdom
                Author notes
                Corresponding Author: Julia R Pozuelo julia_ruizpozuelo@ 123456hms.harvard.edu
                Author information
                https://orcid.org/0000-0002-3058-0371
                https://orcid.org/0000-0003-2845-0380
                https://orcid.org/0009-0005-5846-0573
                https://orcid.org/0009-0007-8497-2171
                https://orcid.org/0000-0003-4915-5356
                https://orcid.org/0000-0001-7068-9294
                https://orcid.org/0000-0002-8887-1374
                https://orcid.org/0000-0003-2530-6885
                https://orcid.org/0000-0003-3458-430X
                https://orcid.org/0000-0002-3704-5240
                https://orcid.org/0000-0001-6061-933X
                https://orcid.org/0000-0001-8207-2822
                Article
                v12i1e59381
                10.2196/59381
                11695961
                39700489
                318b7d3c-81f4-4de1-98c1-2dd55d964f42
                ©Julia R Pozuelo, Christine Nabulumba, Doreen Sikoti, Meghan Davis, Joy Louise Gumikiriza-Onoria, Eugene Kinyanda, Bianca Moffett, Alastair van Heerden, Heather A O'Mahen, Michelle Craske, DoBAt & Ebikolwa Consortium, Munshi Sulaiman, Alan Stein. Originally published in JMIR Serious Games (https://games.jmir.org), 19.12.2024.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Serious Games, is properly cited. The complete bibliographic information, a link to the original publication on https://games.jmir.org, as well as this copyright and license information must be included.

                History
                : 15 April 2024
                : 27 July 2024
                : 29 October 2024
                : 6 November 2024
                Categories
                Original Paper
                Original Paper

                adolescents,mental health,uganda,gamified app,digital interventions,mobile phone,user-centered design,low- and middle-income countries

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