High-fructose feeding promotes accelerated degradation of hepatic LDL receptor and hypercholesterolemia in hamsters via elevated circulating PCSK9 levels.

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Abstract

High fructose diet (HFD) induces dyslipidemia and insulin resistance in experimental animals and humans with incomplete mechanistic understanding. By utilizing mice and hamsters as in vivo models, we investigated whether high fructose consumption affects serum PCSK9 and liver LDL receptor (LDLR) protein levels.

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Journal

Journal ID (iso-abbrev): Atherosclerosis

Title: Atherosclerosis

Publisher: Elsevier BV

ISSN (Electronic): 1879-1484

ISSN (Print): 0021-9150

Publication date (Electronic): Apr 2015

Volume: 239

Issue: 2

Affiliations

[1 ] Department of Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA.

[2 ] Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Montreal, QC H2W 1R7, Canada.

[3 ] Department of Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA. Electronic address: Jingwen.Liu@va.gov.

Article

Publisher Item ID: S0021-9150(15)00047-7 Mid ID: NIHMS612437

DOI: 10.1016/j.atherosclerosis.2015.01.013

PMC ID: 4523098

PubMed ID: 25682035

SO-VID: 318770ce-909b-4f03-8b16-6c3b4b5331ad

History

Keywords: Dyslipidemia,Hamsters,High fructose diet,LDL receptor,PCSK9

Data availability:

Keywords: Dyslipidemia, Hamsters, High fructose diet, LDL receptor, PCSK9

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