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      Clinical Application of 3-Dimensional Printing Technology for Patients With Nasal Septal Deformities : A Multicenter Study

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          Abstract

          Studies have shown the controllability and porosity of polycaprolactone as well as the use of 3-dimensional (3-D) printing for nasal reconstruction in animal models. The utility of polycaprolactone with 3-D technology in nasal cartilaginous framework reconstruction in humans remains unknown.

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          Outcomes after nasal septoplasty: results from the Nasal Obstruction Septoplasty Effectiveness (NOSE) study.

          D L Witsell, Jonas T Johnson, Michael K G Stewart … (2004)
          Our goal was to assess disease-specific quality of life outcomes after nasal septoplasty in adults with nasal obstruction. We conducted a prospective observational outcomes multicenter study with 14 sites and 16 investigators, including private practice and academic settings. Patients had had septal deviation and symptomatic nasal obstruction for at least 3 months, and medical management had failed. Patients with septal deviation completed a validated outcomes instrument (the Nasal Obstruction Septoplasty Effectiveness [NOSE] scale) before and 3 and 6 months after septoplasty, with or without partial turbinectomy. Fifty-nine patients underwent surgery; there was a significant improvement in mean NOSE score at 3 months after septoplasty (67.5 versus 23.1, P < 0.0001), and this improvement was unchanged at 6 months. Patient satisfaction was very high, and patients used significantly fewer nasal medications. In patients with septal deformity, nasal septoplasty results in significant improvement in disease-specific quality of life, high patient satisfaction, and decreased medication use.
          Article 0 comments Cited 75 times – based on 0 reviews     Review now
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            Tissue engineering: from biology to biological substitutes.

            A Sambanis, R M Nerem (1994)
            Tissue engineering is an emerging multidisciplinary and interdisciplinary field involving the development of bioartificial implants and/or the fostering of tissue remodeling with the purpose of repairing or enhancing tissue or organ function. Bioartificial constructs generally consist of cells and biomaterials, so tissue engineering draws from both cell and biomaterials science and technology. Successful applications require a thorough understanding of the environment experienced by cells in normal tissues and by cells in bioartificial devices before and after implantation. This paper reviews these topics, as well as the current status and future possibilities in the development of different bioartificial constructs, including bioartificial skin, cardiovascular implants, bioartificial pancreas, and encapsulated secretory cells. Issues that need to be addressed in the future are also discussed. These include, but are not limited to, the development of new cell lines and biomaterials, the evaluation of the optimal construct architecture, and the reproducible manufacture and preservation of bioartificial devices until ready for use.
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              Three-Dimensional Printing and Its Applications in Otorhinolaryngology-Head and Neck Surgery.

              Trevor Crafts, Avinash Mantravadi, Taha Shipchandler … (2017)
              Objective Three-dimensional (3D)-printing technology is being employed in a variety of medical and surgical specialties to improve patient care and advance resident physician training. As the costs of implementing 3D printing have declined, the use of this technology has expanded, especially within surgical specialties. This article explores the types of 3D printing available, highlights the benefits and drawbacks of each methodology, provides examples of how 3D printing has been applied within the field of otolaryngology-head and neck surgery, discusses future innovations, and explores the financial impact of these advances. Data Sources Articles were identified from PubMed and Ovid MEDLINE. Review Methods PubMed and Ovid Medline were queried for English articles published between 2011 and 2016, including a few articles prior to this time as relevant examples. Search terms included 3-dimensional printing, 3 D printing, otolaryngology, additive manufacturing, craniofacial, reconstruction, temporal bone, airway, sinus, cost, and anatomic models. Conclusions Three-dimensional printing has been used in recent years in otolaryngology for preoperative planning, education, prostheses, grafting, and reconstruction. Emerging technologies include the printing of tissue scaffolds for the auricle and nose, more realistic training models, and personalized implantable medical devices. Implications for Practice After the up-front costs of 3D printing are accounted for, its utilization in surgical models, patient-specific implants, and custom instruments can reduce operating room time and thus decrease costs. Educational and training models provide an opportunity to better visualize anomalies, practice surgical technique, predict problems that might arise, and improve quality by reducing mistakes.
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                Author and article information

                Journal
                Title: JAMA Otolaryngology–Head & Neck Surgery
                Abbreviated Title: JAMA Otolaryngol Head Neck Surg
                Publisher: American Medical Association (AMA)
                ISSN (Print): 2168-6181
                Publication date (Electronic): September 20 2018
                Affiliations
                [1 ]Department of Otolaryngology–Head and Neck Surgery, Seoul St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea
                [2 ]Department of Mechanical Engineering, Korea Polytechnic University, Siheung-Si, Gyeonggi-Do, South Korea
                [3 ]Research Institute, T&R Biofab Co Ltd, Siheung-Si, Gyeonggi-Do, South Korea
                [4 ]Department of Otolaryngology–Head and Neck Surgery, Bucheon St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea
                Article
                DOI: 10.1001/jamaoto.2018.2054
                PMC ID: 6583092
                PubMed ID: 30326042
                SO-VID: 316488ed-7fe6-4d21-8aaa-7a4b494c151c
                Copyright © © 2018
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