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      The importance of free radicals and catalytic metal ions in human diseases

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      Molecular Aspects of Medicine
      Elsevier BV

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          Oxygen-derived free radicals in postischemic tissue injury.

          J M McCord (1985)
          It is now clear that oxygen-derived free radicals play an important part in several models of experimentally induced reperfusion injury. Although there are certainly multiple components to clinical ischemic and reperfusion injury, it appears likely that free-radical production may make a major contribution at certain stages in the progression of the injury. The primary source of superoxide in reperfused reoxygenated tissues appears to be the enzyme xanthine oxidase, released during ischemia by a calcium-triggered proteolytic attack on xanthine dehydrogenase. Reperfused tissues are protected in a variety of laboratory models by scavengers of superoxide radicals or hydroxyl radicals or by allopurinol or other inhibitors of xanthine oxidase. Dysfunction induced by free radicals may thus be a major component of ischemic diseases of the heart, bowel, liver, kidney, and brain.
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            The biology of oxygen radicals

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              Superoxide dismutases.

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                Author and article information

                Journal
                Molecular Aspects of Medicine
                Molecular Aspects of Medicine
                Elsevier BV
                00982997
                January 1985
                January 1985
                : 8
                : 2
                : 89-193
                Article
                10.1016/0098-2997(85)90001-9
                313706ba-d145-4785-aebd-58182cc426e9
                © 1985

                http://www.elsevier.com/tdm/userlicense/1.0/

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