Differential contribution of monocytes to heart macrophages in steady-state and after myocardial infarction.

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Abstract

Macrophages populate the steady-state myocardium. Previously, all macrophages were thought to arise from monocytes; however, it emerged that, in several organs, tissue-resident macrophages may self-maintain through local proliferation.

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Author and article information

Journal

Journal ID (iso-abbrev): Circ. Res.

Title: Circulation research

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1524-4571

ISSN (Print): 0009-7330

Publication date (Electronic): Jul 07 2014

Volume: 115

Issue: 2

Affiliations

[1 ] From the Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston (T.H., G.C., P.D., H.B.S., M.S., Y.I., Y.S., N.D.S., F.K.S., R.W., M.N.); Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, AL (P.P.); Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (A.M.v.d.L.); and Department of Systems Biology, Harvard Medical School, Boston, MA (R.W.).

[2 ] From the Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston (T.H., G.C., P.D., H.B.S., M.S., Y.I., Y.S., N.D.S., F.K.S., R.W., M.N.); Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, AL (P.P.); Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (A.M.v.d.L.); and Department of Systems Biology, Harvard Medical School, Boston, MA (R.W.). mnahrendorf@mgh.harvard.edu.

Article

Publisher Item ID: CIRCRESAHA.115.303567 Mid ID: NIHMS592259

DOI: 10.1161/CIRCRESAHA.115.303567

PMC ID: 4082439

PubMed ID: 24786973

SO-VID: 3111d6e1-3c99-4a11-9e43-7c06d8343f1b

History

Keywords: heart,macrophages,monocytes,myocardial infarction

Data availability:

Keywords: heart, macrophages, monocytes, myocardial infarction

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