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      Emerging pollutants in the EU: 10 years of NORMAN in support of environmental policies and regulations

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          Abstract

          In 2005, the European Commission funded the NORMAN project to promote a permanent network of reference laboratories and research centers, including academia, industry, standardization bodies, and NGOs. Since then, NORMAN has (i) facilitated a more rapid and wide-scope exchange of data on the occurrence and effects of contaminants of emerging concern (CECs), (ii) improved data quality and comparability via validation and harmonization of common sampling and measurement methods (chemical and biological), (iii) provided more transparent information and monitoring data on CECs, and (iv) established an independent and competent forum for the technical/scientific debate on issues related to emerging substances. NORMAN plays a significant role as an independent organization at the interface between science and policy, with the advantage of speaking to the European Commission and other public institutions with the “bigger voice” of more than 70 members from 20 countries. This article provides a summary of the first 10 years of the NORMAN network. It takes stock of the work done so far and outlines NORMAN’s vision for a Europe-wide collaboration on CECs and sustainable links from research to policy-making. It contains an overview of the state of play in prioritizing and monitoring emerging substances with reference to several innovative technologies and monitoring approaches. It provides the point of view of the NORMAN network on a burning issue—the regulation of CECs—and presents the positions of various stakeholders in the field (DG ENV, EEA, ECHA, and national agencies) who participated in the NORMAN workshop in October 2016. The main messages and conclusions from the round table discussions are briefly presented.

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          Tackling antibiotic resistance: the environmental framework.

          Antibiotic resistance is a threat to human and animal health worldwide, and key measures are required to reduce the risks posed by antibiotic resistance genes that occur in the environment. These measures include the identification of critical points of control, the development of reliable surveillance and risk assessment procedures, and the implementation of technological solutions that can prevent environmental contamination with antibiotic resistant bacteria and genes. In this Opinion article, we discuss the main knowledge gaps, the future research needs and the policy and management options that should be prioritized to tackle antibiotic resistance in the environment.
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            Nontarget Screening with High Resolution Mass Spectrometry in the Environment: Ready to Go?

            The vast, diverse universe of organic pollutants is a formidable challenge for environmental sciences, engineering, and regulation. Nontarget screening (NTS) based on high resolution mass spectrometry (HRMS) has enormous potential to help characterize this universe, but is it ready to go for real world applications? In this Feature article we argue that development of mass spectrometers with increasingly high resolution and novel couplings to both liquid and gas chromatography, combined with the integration of high performance computing, have significantly widened our analytical window and have enabled increasingly sophisticated data processing strategies, indicating a bright future for NTS. NTS has great potential for treatment assessment and pollutant prioritization within regulatory applications, as highlighted here by the case of real-time pollutant monitoring on the River Rhine. We discuss challenges for the future, including the transition from research toward solution-centered and robust, harmonized applications.
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              Non-target screening with high-resolution mass spectrometry: critical review using a collaborative trial on water analysis.

              In this article, a dataset from a collaborative non-target screening trial organised by the NORMAN Association is used to review the state-of-the-art and discuss future perspectives of non-target screening using high-resolution mass spectrometry in water analysis. A total of 18 institutes from 12 European countries analysed an extract of the same water sample collected from the River Danube with either one or both of liquid and gas chromatography coupled with mass spectrometry detection. This article focuses mainly on the use of high resolution screening techniques with target, suspect, and non-target workflows to identify substances in environmental samples. Specific examples are given to emphasise major challenges including isobaric and co-eluting substances, dependence on target and suspect lists, formula assignment, the use of retention information, and the confidence of identification. Approaches and methods applicable to unit resolution data are also discussed. Although most substances were identified using high resolution data with target and suspect-screening approaches, some participants proposed tentative non-target identifications. This comprehensive dataset revealed that non-target analytical techniques are already substantially harmonised between the participants, but the data processing remains time-consuming. Although the objective of a "fully-automated identification workflow" remains elusive in the short term, important steps in this direction have been taken, exemplified by the growing popularity of suspect screening approaches. Major recommendations to improve non-target screening include better integration and connection of desired features into software packages, the exchange of target and suspect lists, and the contribution of more spectra from standard substances into (openly accessible) databases. Graphical Abstract Matrix of identification approach versus identification confidence.
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                Author and article information

                Contributors
                valeria.dulio@ineris.fr
                bert.vanbavel@niva.no
                eva.bl@ivl.se
                joop.harmsen@wur.nl
                Juliane.Hollender@eawag.ch
                Martin.Schlabach@nilu.no
                slobodnik@ei.sk
                kevin.thomas@niva.no
                jan.koschorreck@uba.de
                Journal
                Environ Sci Eur
                Environ Sci Eur
                Environmental Sciences Europe
                Springer Berlin Heidelberg (Berlin/Heidelberg )
                2190-4707
                2190-4715
                22 February 2018
                22 February 2018
                2018
                : 30
                : 1
                : 5
                Affiliations
                [1 ]ISNI 0000 0001 2177 3043, GRID grid.8453.a, INERIS, National Institute for Environment and Industrial Risks, ; Verneuil-en-Halatte, France
                [2 ]ISNI 0000 0004 0447 9960, GRID grid.6407.5, NIVA, Norwegian Institute for Water Research, ; Oslo, Norway
                [3 ]ISNI 0000 0000 9987 7806, GRID grid.5809.4, IVL, Swedish Environmental Research Institute, ; Stockholm, Sweden
                [4 ]Wageningen Environmental Research, Wageningen, The Netherlands
                [5 ]ISNI 0000 0001 1551 0562, GRID grid.418656.8, Eawag, ; Dübendorf, Switzerland
                [6 ]ISNI 0000 0000 9888 6866, GRID grid.19169.36, NILU, Norwegian Institute for Air Research, ; Kjeller, Norway
                [7 ]GRID grid.433966.d, Environmental Institute, ; Kos, Slovakia
                [8 ]ISNI 0000 0004 0554 9748, GRID grid.425100.2, UBA, Federal Environment Agency, ; Dessau-Roßlau, Germany
                Author information
                http://orcid.org/0000-0002-9436-9954
                Article
                135
                10.1186/s12302-018-0135-3
                5846969
                29375955
                2ff937fc-ee96-4d59-bae8-ad2ad9b25cd0
                © The Author(s) 2018

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

                History
                : 25 October 2017
                : 22 January 2018
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                © The Author(s) 2018

                norman network,emerging substances,contaminants of emerging concern,science-to-policy,environmental monitoring

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