LINC00313 facilitates osteosarcoma carcinogenesis and metastasis through enhancing EZH2 mRNA stability and EZH2-mediated silence of PTEN expression.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Osteosarcoma is one of the five leading causes of cancer death among all pediatric malignancies. Recent advances in non-coding RNAs suggested that many long noncoding RNAs (lncRNAs) are dysregulated in cancer tissues and play important roles in carcinogenesis. We aimed to further explore the mechanisms of Long Intergenic Non-Protein Coding RNA 313 (LINC00313)-promoted malignant phenotypes of osteosarcoma.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Cell Mol Life Sci

Title: Cellular and molecular life sciences : CMLS

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1420-9071

ISSN (Print): 1420-682X

Publication date (Electronic): Jun 25 2022

Volume: 79

Issue: 7

Affiliations

[1 ] Department of Orthopedics, First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79, Qingchun Road, Hangzhou, 310003, Zhejiang Province, China. xing@zju.edu.cn.

[2 ] Department of Orthopedics, First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79, Qingchun Road, Hangzhou, 310003, Zhejiang Province, China.

[3 ] Department of Radiotherapy, The People's Hospital of Changxing County, Huzhou, 313199, Zhejiang Province, China.

[4 ] Department of Emergency, Qilu Hospital, Shandong University, Jinan, 250063, Shandong Province, China.

Article

Publisher Item ID: 10.1007/s00018-022-04376-1

DOI: 10.1007/s00018-022-04376-1

PubMed ID: 35751755

SO-VID: 2fa763ea-e42c-4d1f-b547-31092b76e409

History

Keywords: Osteosarcoma,EZH2,LINC00313,Metastasis,PTEN/AKT signaling

Data availability:

Keywords: Osteosarcoma, EZH2, LINC00313, Metastasis, PTEN/AKT signaling

Comments

Comment on this article

scite_

Cited by 7

See all cited by