Sub-optimal responders following controlled ovarian stimulation: an overlooked group?

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Abstract

Individualization of IVF treatment and tailored stimulation based on predicted ovarian response may maximize treatment success and minimize the risks following IVF. Whilst there has been a consensus in defining poor ovarian response and an attempt to elucidate the threshold for excessive ovarian response based on the number of oocytes retrieved following ovarian stimulation, no systematic effort has been made in order to refine the oocyte yield thresholds for a normal responder. In this opinion article we discuss the evidence behind the oocyte number thresholds for the ovarian response categories and present the rationale and merits in recognizing a new, overlooked, ovarian response group: The sub-optimal ovarian responders.

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Author and article information

Journal

Journal ID (iso-abbrev): Hum. Reprod.

Title: Human reproduction (Oxford, England)

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1460-2350

ISSN (Print): 0268-1161

Publication date (Electronic): Sep 2015

Volume: 30

Issue: 9

Affiliations

[1 ] Center for Reproductive Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium Department of Clinical Medicine, Faculty of Health, University of Aarhus, Aarhus, Denmark n.polyzos@gmail.com nikolaos.polyzos@uzbrussel.be.

[2 ] Aberdeen Fertility Centre, Aberdeen Maternity Hospital, University of Aberdeen, Aberdeen, UK.

Article

Publisher Item ID: dev149

DOI: 10.1093/humrep/dev149

PubMed ID: 26202582

SO-VID: 2f8abbaa-511d-4a7f-bb29-defa8d96933d

History

Keywords: controlled ovarian stimulation,sub-optimal responders,tailored ovarian stimulation,ovarian response,individualized IVF

Data availability:

Keywords: controlled ovarian stimulation, sub-optimal responders, tailored ovarian stimulation, ovarian response, individualized IVF

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