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      The regulatory role of antisense lncRNAs in cancer

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          Abstract

          Antisense long non-coding RNAs (antisense lncRNAs), transcribed from the opposite strand of genes with either protein coding or non-coding function, were reported recently to play a crucial role in the process of tumor onset and development. Functionally, antisense lncRNAs either promote or suppress cancer cell proliferation, migration, invasion, and chemoradiosensitivity. Mechanistically, they exert their regulatory functions through epigenetic, transcriptional, post-transcriptional, and translational modulations. Simultaneously, because of nucleotide sequence complementarity, antisense lncRNAs have a special role on its corresponding sense gene. We highlight the functions and molecular mechanisms of antisense lncRNAs in cancer tumorigenesis and progression. We also discuss the potential of antisense lncRNAs to become cancer diagnostic biomarkers and targets for tumor treatment.

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          MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

          Rajesha Rupaimoole, Frank J Slack (2017)
          MicroRNAs (miRNAs) are small non-coding RNAs that can modulate mRNA expression. Insights into the roles of miRNAs in development and disease have led to the development of new therapeutic approaches that are based on miRNA mimics or agents that inhibit their functions (antimiRs), and the first such approaches have entered the clinic. This Review discusses the role of different miRNAs in cancer and other diseases, and provides an overview of current miRNA therapeutics in the clinic.
          Article 0 comments Cited 1420 times – based on 0 reviews     Review now
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            Long Noncoding RNA and Cancer: A New Paradigm.

            Milad Soleimani, Subhrangsu Mandal, Arunoday Bhan (2017)
            In addition to mutations or aberrant expression in the protein-coding genes, mutations and misregulation of noncoding RNAs, in particular long noncoding RNAs (lncRNA), appear to play major roles in cancer. Genome-wide association studies of tumor samples have identified a large number of lncRNAs associated with various types of cancer. Alterations in lncRNA expression and their mutations promote tumorigenesis and metastasis. LncRNAs may exhibit tumor-suppressive and -promoting (oncogenic) functions. Because of their genome-wide expression patterns in a variety of tissues and their tissue-specific expression characteristics, lncRNAs hold strong promise as novel biomarkers and therapeutic targets for cancer. In this article, we have reviewed the emerging functions and association of lncRNAs in different types of cancer and discussed their potential implications in cancer diagnosis and therapy. Cancer Res; 77(15); 3965-81. ©2017 AACR.
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              Long Noncoding RNAs in Cancer Pathways.

              Adam Schmitt, Howard Y. Chang (2016)
              Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now understand that lncRNAs drive many important cancer phenotypes through their interactions with other cellular macromolecules including DNA, protein, and RNA. Recent advancements in surveying lncRNA molecular mechanisms are now providing the tools to functionally annotate these cancer-associated transcripts, making these molecules attractive targets for therapeutic intervention in the fight against cancer.
              Article 0 comments Cited 904 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Jianye Liu:
                ORCID: http://orcid.org/0000-0002-7953-3672
                liujianye810@163.com
                Journal
                Journal ID (nlm-ta): Cancer Cell Int
                Journal ID (iso-abbrev): Cancer Cell Int
                Title: Cancer Cell International
                Publisher: BioMed Central (London )
                ISSN (Electronic): 1475-2867
                Publication date (Electronic): 30 August 2021
                Publication date PMC-release: 30 August 2021
                Publication date Collection: 2021
                Volume: 21
                Electronic Location Identifier: 459
                Affiliations
                GRID grid.431010.7, Department of Urology, , The Third Xiangya Hospital of Central South University, ; No.138, Tongzipo Road, Changsha, 410013 Hunan China
                Author information
                http://orcid.org/0000-0002-7953-3672
                Article
                Publisher ID: 2168
                DOI: 10.1186/s12935-021-02168-4
                PMC ID: 8404292
                PubMed ID: 34461912
                SO-VID: 2f822520-8fc9-43c5-b1ed-c66436302144
                Copyright © © The Author(s) 2021
                License:

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

                History
                Date received : 30 April 2021
                Date accepted : 20 August 2021
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/501100001809, National Natural Science Foundation of China;
                Award ID: 81802556
                Award Recipient :
                Funded by: FundRef http://dx.doi.org/10.13039/501100004735, Natural Science Foundation of Hunan Province;
                Award ID: 2019JJ30039
                Award Recipient :
                Funded by: Huxiang Young Talents Plan Project of Hunan Province
                Award ID: 2019RS2015
                Award Recipient :
                Funded by: the New Xiangya Talent Projects of the Third Xiangya Hospital of Central South University
                Award ID: JY201615
                Award Recipient :
                Funded by: the Scientific Projects of Changsha Administration of Science &Technology
                Award ID: kq1901129
                Award Recipient :
                Funded by: the Scientific Projects of Health Commission of Hunan Province
                Award ID: B2017034
                Award ID: 20201041
                Award Recipient :
                Categories
                Subject: Review
                Custom metadata
                issue-copyright-statement © The Author(s) 2021

                ScienceOpen disciplines: Oncology & Radiotherapy
                Keywords: antisense lncrna,cancer,transcriptional modulation,translational control,target therapy
                Data availability:
                ScienceOpen disciplines: Oncology & Radiotherapy
                Keywords: antisense lncrna, cancer, transcriptional modulation, translational control, target therapy

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