Research on stem cell therapy for spinal cord injury: a bibliometric and visual analysis from 2018–2023

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Abstract

Objectives: The aim of this study was to conduct a bibliometric analysis of the literature on stem cell treatment for spinal cord injury to gain an intuitive understanding of how the field is progressing, discover topics of interest, and determine what development trends are emerging in this field.

Background: Spinal cord injury and its complications often cause an enormous economic burden, and postinjury repair and treatment have always been challenging in clinical and scientific research. Stem cell therapy for spinal cord injury can prevent immune rejection and induce the release of neuroprotective and anti-inflammatory factors to reduce the production of stress-related proteins, reactive oxygen species, and inflammatory reactions.

Methods: We analyzed the number and quality of publications in the field of stem cell therapy in spinal cord injury between 2018.01.01 and 2023.06.30 in the core collection database of Web of Science. CiteSpace and VOSviewer were used to sort and summarize these studies by country, institution, authors' publications, and collaborative networks. In addition, the research topics of interest were identified and summarized.

Results: This study ultimately included 2,150 valid papers, with the number of publications showing a gradual upward trend. The country, institution, author and journal with the greatest number of publications and citations are China, the Chinese Academy of Sciences, Dai JW, and the International Journal of Molecular Sciences, respectively. The top three high-frequency keyword clusters were hereditary paraplegia, reactive astrocytes and tissue engineering.

Conclusion: With the help of visual analysis, we identified general trends and research topics of interest in the field of spinal cord injury over the last 5 years. Our findings suggest that stem cell transplantation for spinal cord injury and exosome therapy may be a focus of future research. This study provides a foundation for future research on stem cell therapy as well as clinical efforts in this field.

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The study of extracellular vesicles (EVs) has the potential to identify unknown cellular and molecular mechanisms in intercellular communication and in organ homeostasis and disease. Exosomes, with an average diameter of ~100 nanometers, are a subset of EVs. The biogenesis of exosomes involves their origin in endosomes, and subsequent interactions with other intracellular vesicles and organelles generate the final content of the exosomes. Their diverse constituents include nucleic acids, proteins, lipids, amino acids, and metabolites, which can reflect their cell of origin. In various diseases, exosomes offer a window into altered cellular or tissue states, and their detection in biological fluids potentially offers a multicomponent diagnostic readout. The efficient exchange of cellular components through exosomes can inform their applied use in designing exosome-based therapeutics.

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Reactive Astrocytes: Production, Function, and Therapeutic Potential.

Ben A. Barres, Shane Liddelow (2017)

Astrocytes constitute approximately 30% of the cells in the mammalian central nervous system (CNS). They are integral to brain and spinal-cord physiology and perform many functions important for normal neuronal development, synapse formation, and proper propagation of action potentials. We still know very little, however, about how these functions change in response to immune attack, chronic neurodegenerative disease, or acute trauma. In this review, we summarize recent studies that demonstrate that different initiating CNS injuries can elicit at least two types of "reactive" astrocytes with strikingly different properties, one type being helpful and the other harmful. We will also discuss new methods for purifying and investigating reactive-astrocyte functions and provide an overview of new markers for delineating these different states of reactive astrocytes. The discovery that astrocytes have different types of reactive states has important implications for the development of new therapies for CNS injury and diseases.

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Author and article information

Contributors

Ruxing Liu: Role:

Bo Peng: Role: Role:

Jie Yuan: Role: Role: Role: Role:

Jiahao Hu: Role: Role:

Jianxin Yang: Role:

Nan Shan: Role:

Qichao Li: Role:

Bin Zhao: Role:

Chaojian Xu: URI : https://loop.frontiersin.org/people/2615734/overviewRole:

Yongfeng Wang: URI : https://loop.frontiersin.org/people/2393026/overview

Journal

Journal ID (nlm-ta): Front Genet

Journal ID (iso-abbrev): Front Genet

Journal ID (publisher-id): Front. Genet.

Title: Frontiers in Genetics

Publisher: Frontiers Media S.A.

ISSN (Electronic): 1664-8021

Publication date (Electronic): 06 February 2024

Publication date Collection: 2024

Volume: 15

Electronic Location Identifier: 1327216

Affiliations

[1] ¹ Department of Orthopedics , Second Hospital of Shanxi Medical University , Taiyuan, China

[2] ² Department of Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair , Second Hospital of Shanxi Medical University , Taiyuan, China

[3] ³ Department of Pain Management , Second Hospital of Shanxi Medical University , Taiyuan, China

[4] ⁴ The Second Hospital of Shanxi Medical University , Taiyuan, China

Author notes

Edited by: Víctor Carriel, University of Granada, Spain

Reviewed by: Miguel Angel Martin-Piedra, University of Granada, Spain

Yuyao Tian, Massachusetts General Hospital and Harvard Medical School, United States

*Correspondence: Yongfeng Wang, wyfwf8@ 123456163.com ; Chaojian Xu, xcj304@ 123456163.com

Article

Publisher ID: 1327216

DOI: 10.3389/fgene.2024.1327216

PMC ID: 10877028

PubMed ID: 38380424

SO-VID: 2f514509-5af9-4554-82a7-d3c871c4bba6

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

History

Date received : 24 October 2023

Date accepted : 19 January 2024

Funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by General Program of Natural Science Research of Shanxi Basic Research Program (202203021212060, 202203021211040, and 20210302124670); Shanxi Provincial Health Commission major science and technology research project (2021XM10).