For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
32
views
93
references
 Top references
cited by
396
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      632
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Engineering exosomes for targeted drug delivery

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Exosomes are cell-derived nanovesicles that are involved in the intercellular transportation of materials. Therapeutics, such as small molecules or nucleic acid drugs, can be incorporated into exosomes and then delivered to specific types of cells or tissues to realize targeted drug delivery. Targeted delivery increases the local concentration of therapeutics and minimizes side effects. Here, we present a detailed review of exosomes engineering through genetic and chemical methods for targeted drug delivery. Although still in its infancy, exosome-mediated drug delivery boasts low toxicity, low immunogenicity, and high engineerability, and holds promise for cell-free therapies for a wide range of diseases.

          Related collections

          Most cited references93

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

          Clotilde Théry, Kenneth W Witwer, Elena Aikawa … (2019)
          ABSTRACT The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.
          Article 0 comments Cited 3521 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            The biology, function, and biomedical applications of exosomes

            Raghu Kalluri, Valerie LeBleu (2020)
            The study of extracellular vesicles (EVs) has the potential to identify unknown cellular and molecular mechanisms in intercellular communication and in organ homeostasis and disease. Exosomes, with an average diameter of ~100 nanometers, are a subset of EVs. The biogenesis of exosomes involves their origin in endosomes, and subsequent interactions with other intracellular vesicles and organelles generate the final content of the exosomes. Their diverse constituents include nucleic acids, proteins, lipids, amino acids, and metabolites, which can reflect their cell of origin. In various diseases, exosomes offer a window into altered cellular or tissue states, and their detection in biological fluids potentially offers a multicomponent diagnostic readout. The efficient exchange of cellular components through exosomes can inform their applied use in designing exosome-based therapeutics.
            Article 0 comments Cited 2779 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

              Mathilde Mathieu, Lorena Martin-Jaular, Gregory Lavieu … (2019)
              The ability of exosomes to transfer cargo from donor to acceptor cells, thereby triggering phenotypic changes in the latter, has generated substantial interest in the scientific community. However, the extent to which exosomes differ from other extracellular vesicles in terms of their biogenesis and functions remains ill-defined. Here, we discuss the current knowledge on the specificities of exosomes and other types of extracellular vesicles, and their roles as important agents of cell-to-cell communication.
              Article 0 comments Cited 1280 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Theranostics
                Journal ID (iso-abbrev): Theranostics
                Journal ID (publisher-id): thno
                Title: Theranostics
                Publisher: Ivyspring International Publisher (Sydney )
                ISSN (Electronic): 1838-7640
                Publication date Collection: 2021
                Publication date (Electronic): 1 January 2021
                Volume: 11
                Issue: 7
                Pages: 3183-3195
                Affiliations
                [1 ]Department of Child and Adolescent Psychiatry, Shenzhen Kangning Hospital, Shenzhen Mental Health Center, Shenzhen Key Laboratory for Psychological Healthcare & Shenzhen Institute of Mental Health, Shenzhen, 518020, China
                [2 ]Department of Chemistry, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
                [3 ]Department of Orthopedics, Shenzhen Second People's Hospital (First Affiliated Hospital of Shenzhen University, Health Science Center), Shenzhen 518035, China
                Author notes
                ✉ Corresponding authors: Jiang Xia, Department of Chemistry, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China ( jiangxia@ 123456cuhk.edu.hk ). Jianping Lu, Shenzhen Kangning Hospital, No. 1080, Cuizhu Rd., Luohu District, Shenzhen, Guangdong 518020, PR China (e-mail: szlujianping@ 123456126.com ). ORCID: Yujie Liang: 0000-0002-0860-4859; Jiang Xia: 0000-0001-8112-7625

                Competing Interests: The authors have declared that no competing interest exists.

                Article
                Publisher ID: thnov11p3183
                DOI: 10.7150/thno.52570
                PMC ID: 7847680
                PubMed ID: 33537081
                SO-VID: 2e11b030-d4d8-450a-b9a2-319571493965
                Copyright © © The author(s)
                License:

                This is an open access article distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

                History
                Date received : 29 August 2020
                Date accepted : 22 December 2020
                Categories
                Subject: Review

                ScienceOpen disciplines: Molecular medicine
                Keywords: exosomes,targeted delivery,chemical modification,genetic engineering, exosomal membrane proteins
                Data availability:
                ScienceOpen disciplines: Molecular medicine
                Keywords: exosomes, targeted delivery, chemical modification, genetic engineering, exosomal membrane proteins

                Comments

                Comment on this article

                scite_

                Similar content632

                See all similar

                Cited by394

                See all cited by

                Most referenced authors3,971

                See all reference authors