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      Design, synthesis and herbicidal activity of novel quinazoline-2,4-diones as 4-hydroxyphenylpyruvate dioxygenase inhibitors.

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          Abstract

          4-Hydroxyphenylpyruvate dioxygenase (HPPD) (EC 1.13.11.27) has been identified as one of the most promising target sites for herbicide discovery. To discover novel HPPD inhibitors with high herbicidal activity and improved crop selectivity, a series of novel triketone-containing quinazoline-2,4-dione derivatives possessing a variety of substituents at the N-1 position of the quinazoline-2,4-dione ring were designed and synthesised.

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          Author and article information

          Journal
          Pest Manag. Sci.
          Pest management science
          Wiley-Blackwell
          1526-4998
          1526-498X
          Aug 2015
          : 71
          : 8
          Affiliations
          [1 ] Key Laboratory of Pesticide and Chemical Biology, College of Chemistry, Central China Normal University, Wuhan, China.
          [2 ] Collaborative Innovation Centre of Chemical Science and Engineering, Tianjin, China.
          Article
          10.1002/ps.3894
          25185782
          2decf5db-0b8e-4254-af4d-02227427f1a9
          History

          weed control,4-hydroxyphenylpyruvate dioxygenase,herbicide,structure-activity relationship,quinazoline-2,4-dione

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