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      Impact of autocatalytic chemical reaction in an Ostwald-de-Waele nanofluid flow past a rotating disk with heterogeneous catalysis

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          Abstract

          The nanofluids owing to their alluring attributes like enhanced thermal conductivity and better heat transfer characteristics have a vast variety of applications ranging from space technology to nuclear reactors etc. The present study highlights the Ostwald-de-Waele nanofluid flow past a rotating disk of variable thickness in a porous medium with a melting heat transfer phenomenon. The surface catalyzed reaction is added to the homogeneous-heterogeneous reaction that triggers the rate of the chemical reaction. The added feature of the variable thermal conductivity and the viscosity instead of their constant values also boosts the novelty of the undertaken problem. The modeled problem is erected in the form of a system of partial differential equations. Engaging similarity transformation, the set of ordinary differential equations are obtained. The coupled equations are numerically solved by using the bvp4c built-in MATLAB function. The drag coefficient and Nusselt number are plotted for arising parameters. The results revealed that increasing surface catalyzed parameter causes a decline in thermal profile more efficiently. Further, the power-law index is more influential than the variable thickness disk index. The numerical results show that variations in dimensionless thickness coefficient do not make any effect. However, increasing power-law index causing an upsurge in radial, axial, tangential, velocities, and thermal profile.

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          Re-epithelialization and immune cell behaviour in an ex vivo human skin model

          A large body of literature is available on wound healing in humans. Nonetheless, a standardized ex vivo wound model without disruption of the dermal compartment has not been put forward with compelling justification. Here, we present a novel wound model based on application of negative pressure and its effects for epidermal regeneration and immune cell behaviour. Importantly, the basement membrane remained intact after blister roof removal and keratinocytes were absent in the wounded area. Upon six days of culture, the wound was covered with one to three-cell thick K14+Ki67+ keratinocyte layers, indicating that proliferation and migration were involved in wound closure. After eight to twelve days, a multi-layered epidermis was formed expressing epidermal differentiation markers (K10, filaggrin, DSG-1, CDSN). Investigations about immune cell-specific manners revealed more T cells in the blister roof epidermis compared to normal epidermis. We identified several cell populations in blister roof epidermis and suction blister fluid that are absent in normal epidermis which correlated with their decrease in the dermis, indicating a dermal efflux upon negative pressure. Together, our model recapitulates the main features of epithelial wound regeneration, and can be applied for testing wound healing therapies and investigating underlying mechanisms.
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            Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study

            Our previous study demonstrated increased expression of Heat shock protein (Hsp) 90 in the skin of patients with systemic sclerosis (SSc). We aimed to evaluate plasma Hsp90 in SSc and characterize its association with SSc-related features. Ninety-two SSc patients and 92 age-/sex-matched healthy controls were recruited for the cross-sectional analysis. The longitudinal analysis comprised 30 patients with SSc associated interstitial lung disease (ILD) routinely treated with cyclophosphamide. Hsp90 was increased in SSc compared to healthy controls. Hsp90 correlated positively with C-reactive protein and negatively with pulmonary function tests: forced vital capacity and diffusing capacity for carbon monoxide (DLCO). In patients with diffuse cutaneous (dc) SSc, Hsp90 positively correlated with the modified Rodnan skin score. In SSc-ILD patients treated with cyclophosphamide, no differences in Hsp90 were found between baseline and after 1, 6, or 12 months of therapy. However, baseline Hsp90 predicts the 12-month change in DLCO. This study shows that Hsp90 plasma levels are increased in SSc patients compared to age-/sex-matched healthy controls. Elevated Hsp90 in SSc is associated with increased inflammatory activity, worse lung functions, and in dcSSc, with the extent of skin involvement. Baseline plasma Hsp90 predicts the 12-month change in DLCO in SSc-ILD patients treated with cyclophosphamide.
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              An updated review on application of nanofluids in heat exchangers for saving energy

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                Author and article information

                Contributors
                chuyuming@zjhu.edu.cn
                Journal
                Sci Rep
                Sci Rep
                Scientific Reports
                Nature Publishing Group UK (London )
                2045-2322
                30 July 2021
                30 July 2021
                2021
                : 11
                : 15526
                Affiliations
                [1 ]GRID grid.411629.9, ISNI 0000 0000 8646 3057, School of Science, , Beijing University of Civil Engineering and Architecture, ; Beijing, 100044 People’s Republic of China
                [2 ]GRID grid.411629.9, ISNI 0000 0000 8646 3057, Beijing Key Laboratory of Functional Materials for Building Structure and Environment Remediation, , Beijing University of Civil Engineering and Architecture, ; Beijing, 100044 People’s Republic of China
                [3 ]GRID grid.444787.c, ISNI 0000 0004 0607 2662, Department of Computer Science, , Bahria University, ; Islamabad, 44000 Pakistan
                [4 ]Faculty of Applied Computing and Technology, Noroff University College, Kristiansand, Norway
                [5 ]GRID grid.411440.4, ISNI 0000 0001 0238 8414, Department of Mathematics, , Huzhou University, ; Huzhou, 313000 People’s Republic of China
                [6 ]GRID grid.440669.9, ISNI 0000 0001 0703 2206, Hunan Provincial Key Laboratory of Mathematical Modeling and Analysis in Engineering, , Changsha University of Science and Technology, ; Changsha, 410114 People’s Republic of China
                [7 ]GRID grid.412144.6, ISNI 0000 0004 1790 7100, Department of Mathematics, College of Sciences, , King Khalid University, ; Abha, 61413 Kingdom of Saudi Arabia
                Article
                94918
                10.1038/s41598-021-94918-7
                8324849
                34330971
                2d7269dd-2d16-45a3-91ca-66d6fdf11089
                © The Author(s) 2021

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 24 May 2021
                : 19 July 2021
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/501100014220, National Natural Science Foundation of China-Henan Joint Fund;
                Award ID: 11971142
                Award ID: 11871202
                Award ID: 61673169
                Award ID: 11701176
                Award ID: 11626101
                Award ID: 11601485
                Award Recipient :
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                © The Author(s) 2021

                Uncategorized
                software,mechanical engineering
                Uncategorized
                software, mechanical engineering

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