Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue fever

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Abstract

In the search for new larvicides from plants, we have investigated the potential activity of the rotenoids deguelin (1), 12a-hydroxy-α-toxicarol (2) and tephrosin (3), isolated from the bioactive ethanol extract of roots of Tephrosia toxicaria Pers., against Aedes aegypti, the main vector of dengue. The absolute configuration of these compounds was determined by circular dichroism (CD) spectra. The LC50 values of the compounds evaluated justify the potential of T. toxicaria as a new natural larvicide.

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Author and article information

Journal

Journal ID (publisher-id): qn

Title: Química Nova

Abbreviated Title: Quím. Nova

Publisher: Sociedade Brasileira de Química (São Paulo, SP, Brazil )

ISSN (Print): 0100-4042

ISSN (Electronic): 1678-7064

Publication date (Print and electronic): 2012

Volume: 35

Issue: 6

Pages: 1097-1100

Affiliations

[03] Fortaleza CE orgnameUniversidade Federal do Ceará orgdiv1Centro de Ciências orgdiv2Departamento de Química Orgânica e Inorgânica Brasil

[02] Fortaleza CE orgnameUniversidade Federal do Ceará orgdiv1Faculdade de Farmácia orgdiv2Departamento de Farmácia Brasil

[04] Seropédica RJ orgnameUniversidade Federal Rural do Rio de Janeiro orgdiv1Instituto de Ciências Exatas orgdiv2Departamento de Química Brasil

[01] Tianguá CE orgnameInstituto Federal de Educação, Ciência e Tecnologia do Ceará Brasil

Article

Publisher ID: S0100-40422012000600005 Publisher ID: S0100-4042(12)03500605

DOI: 10.1590/S0100-40422012000600005

SO-VID: 2d3edfc5-0ecf-41ff-bf71-c545d060d1c2

License:

This work is licensed under a Creative Commons Attribution 4.0 International License.

History

Date received : 29 June 2011

Date accepted : 14 January 2012

Page count

Figures: 0, Tables: 0, Equations: 0, References: 23, Pages: 4

Product

SciELO Brazil

Keywords: rotenoids,Tephrosia toxicaria,Aedes aegypti

Data availability:

Keywords: rotenoids, Tephrosia toxicaria, Aedes aegypti

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