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Niclosamide Exhibits Potent Anticancer Activity and Synergizes with Sorafenib in Human Renal Cell Cancer Cells
Xinyi Yu ,
Feng Liu ,
Liyi Zeng ,
Fang He ,
Ruyi Zhang ,
Shujuan Yan ,
Zongyue Zeng ,
Yi Shu ,
Chen Zhao ,
Xingye Wu ,
Jiayan Lei ,
Wenwen Zhang ,
Chao Yang ,
Ke Wu ,
Ying Wu ,
Liping An ,
Shifeng Huang ,
Xiaojuan Ji ,
Cheng Gong ,
Chengfu Yuan ,
Linghuan Zhang ,
Yixiao Feng ,
Bo Huang ,
Wei Liu ,
Bo Zhang ,
Zhengyu Dai ,
Xi Wang ,
Bo Liu ,
Rex C. Haydon ,
Hue H. Luu ,
Hua Gan ,
Tong-Chuan He ,
Liqun Chen
July 26 2018
May 24 2018
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Abstract
As the most lethal urological cancers, renal cell carcinoma (RCC) comprises a heterogeneous
group of cancer with diverse genetic and molecular alterations. There is an unmet
clinical need to develop efficacious therapeutics for advanced, metastatic and/or
relapsed RCC. Here, we investigate whether anthelmintic drug Niclosamide exhibits
anticancer activity and synergizes with targeted therapy Sorafenib in suppressing
RCC cell proliferation.