Role of microRNAs in programmed cell death in renal diseases: A review

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Abstract

MicroRNAs (miRNAs) regulate gene expression involving kidney morphogenesis and cell proliferation, apoptosis, differentiation, migration, invasion, immune evasion, and extracellular matrix remodeling. Programmed cell death (PCD) is mediated and regulated by specific genes and a wealth of miRNAs, which participate in various pathological processes. Dysregulation of miRNAs can disrupt renal development and induce the onset and progression of various renal diseases. An in-depth understanding of how miRNAs regulate renal development and diseases is indispensable to comprehending how they can be used in new diagnostic and therapeutic approaches. However, the mechanisms are still insufficiently investigated. Hence, we review the current roles of miRNA-related signaling pathways and recent advances in PCD research and aim to display the potential crosstalk between miRNAs and PCD. The prospects of miRNAs as novel biomarkers and therapeutic targets are also described, which might provide some novel ideas for further studies.

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Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

Jacob O'Brien, Heyam Hayder, Yara Zayed … (2018)

MicroRNAs (miRNAs) are a class of non-coding RNAs that play important roles in regulating gene expression. The majority of miRNAs are transcribed from DNA sequences into primary miRNAs and processed into precursor miRNAs, and finally mature miRNAs. In most cases, miRNAs interact with the 3′ untranslated region (3′ UTR) of target mRNAs to induce mRNA degradation and translational repression. However, interaction of miRNAs with other regions, including the 5′ UTR, coding sequence, and gene promoters, have also been reported. Under certain conditions, miRNAs can also activate translation or regulate transcription. The interaction of miRNAs with their target genes is dynamic and dependent on many factors, such as subcellular location of miRNAs, the abundancy of miRNAs and target mRNAs, and the affinity of miRNA-mRNA interactions. miRNAs can be secreted into extracellular fluids and transported to target cells via vesicles, such as exosomes, or by binding to proteins, including Argonautes. Extracellular miRNAs function as chemical messengers to mediate cell-cell communication. In this review, we provide an update on canonical and non-canonical miRNA biogenesis pathways and various mechanisms underlying miRNA-mediated gene regulations. We also summarize the current knowledge of the dynamics of miRNA action and of the secretion, transfer, and uptake of extracellular miRNAs.

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MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

Rajesha Rupaimoole, Frank J Slack (2017)

MicroRNAs (miRNAs) are small non-coding RNAs that can modulate mRNA expression. Insights into the roles of miRNAs in development and disease have led to the development of new therapeutic approaches that are based on miRNA mimics or agents that inhibit their functions (antimiRs), and the first such approaches have entered the clinic. This Review discusses the role of different miRNAs in cancer and other diseases, and provides an overview of current miRNA therapeutics in the clinic.

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miRBase: from microRNA sequences to function

Ana Kozomara, Maria Birgaoanu, Sam Griffiths-Jones (2018)

Abstract miRBase catalogs, names and distributes microRNA gene sequences. The latest release of miRBase (v22) contains microRNA sequences from 271 organisms: 38 589 hairpin precursors and 48 860 mature microRNAs. We describe improvements to the database and website to provide more information about the quality of microRNA gene annotations, and the cellular functions of their products. We have collected 1493 small RNA deep sequencing datasets and mapped a total of 5.5 billion reads to microRNA sequences. The read mapping patterns provide strong support for the validity of between 20% and 65% of microRNA annotations in different well-studied animal genomes, and evidence for the removal of >200 sequences from the database. To improve the availability of microRNA functional information, we are disseminating Gene Ontology terms annotated against miRBase sequences. We have also used a text-mining approach to search for microRNA gene names in the full-text of open access articles. Over 500 000 sentences from 18 542 papers contain microRNA names. We score these sentences for functional information and link them with 12 519 microRNA entries. The sentences themselves, and word clouds built from them, provide effective summaries of the functional information about specific microRNAs. miRBase is publicly and freely available at http://mirbase.org/.

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Author and article information

Contributors

Yan Zhang

Xinghua Lv

Feng Chen

Qian Fan:

ORCID: https://orcid.org/0000-0002-7617-9962

Yongqiang Liu

Zhanhai Wan

Janvier Nibaruta

Jipeng Lv

Xuena Han

Lin Wu

Hao Wang

Journal

Journal ID (nlm-ta): Medicine (Baltimore)

Journal ID (publisher-id): MD

Title: Medicine

Publisher: Lippincott Williams & Wilkins (Hagerstown, MD )

ISSN (Print): 0025-7974

ISSN (Electronic): 1536-5964

Publication date Collection: 14 April 2023

Publication date (Electronic): 14 April 2023

Volume: 102

Issue: 15

Electronic Location Identifier: e33453

Affiliations

[a ] Department of Anesthesiology, First Hospital of Lanzhou University, Lanzhou, Gansu, China

[b ] The First Clinical Medical College of Lanzhou University, Lanzhou, GanSu Province, China

[c ] Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Nankai University Affiliated Eye Hospital, Tianjin, China

[d ] Nankai Eye Institute, Nankai University, Tianjin, China

[e ] Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China.

Author notes

*Correspondence: Yufang Leng, Department of Anesthesiology, First Hospital of Lanzhou University, Lanzhou, 730000, Gansu, China (e-mail: lengyf@ 123456lzu.edu.cn ).

Author information

Qian Fan https://orcid.org/0000-0002-7617-9962

Article

Accession ID: 00063

DOI: 10.1097/MD.0000000000033453

PMC ID: 10101263

SO-VID: 2d13e989-ab56-4c6f-aa99-f06b801b0ddf

License:

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

History

Date received : 13 February 2023

Date received : 14 March 2023

Date accepted : 15 March 2023

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Keywords: apoptosis,autophagy,ferroptosis,micrornas,programmed cell death,pyroptosis

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Keywords: apoptosis, autophagy, ferroptosis, micrornas, programmed cell death, pyroptosis

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Role of microRNAs in programmed cell death in renal diseases: A review

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Genes & Diseases

Most cited references 92

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

miRBase: from microRNA sequences to function

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