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Burden of bacterial bloodstream infection—a brief update on epidemiology and significance of multidrug-resistant pathogens
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Abstract
<p class="first" id="d5911454e69">Bloodstream infections comprise a wide variety of
pathogens and clinical syndromes
with considerable overlap with similar syndromes of non-bacteraemic infections and
diverse risk factors, therapeutic implications and outcomes. Yet, this heterogeneous
'entity' has the advantage to be pathogen-defined compared with the broad and even
more heterogeneous entity 'sepsis', and so has become helpful for clinicians and epidemiologists
for research and surveillance purposes. The increasing availability of population-based
and large multicentre well-defined cohort studies should allow us to assess with much
confidence and in detail its burden, the significance of antimicrobial resistance,
and areas of uncertainty regarding further epidemiological evolution and optimized
treatment regimens.
</p>