TRIM33 prevents pulmonary fibrosis by impairing TGF-β1 signalling.

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Abstract

Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterised by myofibroblast proliferation and abnormal extracellular matrix accumulation in the lungs. Transforming growth factor (TGF)-β1 initiates key profibrotic signalling involving the SMAD pathway and the small heat shock protein B5 (HSPB5). Tripartite motif-containing 33 (TRIM33) has been reported to negatively regulate TGF-β/SMAD signalling, but its role in fibrogenesis remains unknown. The objective of this study was to elucidate the role of TRIM33 in IPF.

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Journal

Journal ID (iso-abbrev): Eur. Respir. J.

Title: The European respiratory journal

Publisher: European Respiratory Society (ERS)

ISSN (Electronic): 1399-3003

ISSN (Print): 0903-1936

Publication date (Electronic): Jun 2020

Volume: 55

Issue: 6

Affiliations

[1 ] INSERM U1231, Faculty of Medicine and Pharmacy, University of Bourgogne-Franche Comté, Dijon, France.

[2 ] Division of Pulmonary Sciences and Critical Care Medicine, Dept of Medicine, University of Colorado Denver, Aurora, CO, USA.

[3 ] Dept of Pulmonary Medicine and Intensive Care Unit, University Hospital, Bourgogne-Franche Comté, Dijon, France.

[4 ] Reference Center for Rare Lung Diseases, University Hospital, Bourgogne-Franche Comté, Dijon, France.

[5 ] Cancer Center Georges François Leclerc, Dijon, France.

[6 ] INSERM U1152, Faculty of Medicine, University of Bichat, Paris, France.

[7 ] McMaster University, Hamilton, ON, Canada.

[8 ] These authors codirected this work and contributed equally to this work.

[9 ] INSERM U1231, Faculty of Medicine and Pharmacy, University of Bourgogne-Franche Comté, Dijon, France philippe.bonniaud@chu-dijon.fr.

Article

Publisher Item ID: 13993003.01346-2019

DOI: 10.1183/13993003.01346-2019

PubMed ID: 32184320

SO-VID: 2bdf41ba-3010-4461-926e-e40c622f3ee4

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