Journal ID (nlm-ta): Proc Natl Acad Sci U S A
Journal ID (iso-abbrev): Proc. Natl. Acad. Sci. U.S.A
Journal ID (hwp): pnas
Journal ID (pmc): pnas
Journal ID (publisher-id): PNAS
Title:
Proceedings of the National Academy of Sciences of the United States of America
Publisher:
National Academy of Sciences
ISSN
(Print):
0027-8424
ISSN
(Electronic):
1091-6490
Publication date
(Print):
31
March
2020
Publication date
(Electronic):
13
March
2020
Publication date PMC-release: 13
March
2020
Volume: 117
Issue: 13
Pages: 7374-7381
Affiliations
[1]
aDepartment of Chemistry, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599-3290;
[2]
bDepartment of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599-7555;
[3]
cCenter for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599-7555;
[4]
dComputational and Systems Medicine, Department of Surgery & Cancer, Imperial College London , SW7 2AZ London, United Kingdom;
[5]
eLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599;
[6]
fDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599-7525;
[7]
gDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599;
[8]
hDepartment of Medicine, Division of Gastroenterology, University of Florida , Gainesville, FL 32610;
[9]
iDepartment of Genetics, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599-7264;
[10]
jDepartment of Biochemistry, Integrated Program for Biological and Genome Science,
University of North Carolina at Chapel Hill , Chapel Hill, NC 27599-3290;
[11]
kDepartment of Biophysics, Integrated Program for Biological and Genome Science, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599-3290
Author notes
Edited by Robert J. Fletterick, University of California, San Francisco, CA, and approved
February 17, 2020 (received for review October 16, 2019)
Author contributions: A.P.B., R.B.S., S.J.B., and M.R.R. designed research; A.P.B.,
S.J.P., K.A.B., W.G.W., B.D.W., B.C.C., M.M.L., J.R.R., and S.A.M. performed research;
A.P.B., S.J.P., K.A.B., B.D.W., B.C.C., M.M.L., J.R.S., I.D.W., D.B.D., S.T.B., R.B.S.,
and R.Z.G. contributed new reagents/analytic tools; A.P.B., S.J.P., K.A.B., W.G.W.,
B.C.C., M.M.L., J.R.S., I.D.W., J.R.R., S.T.B., S.A.M., J.M.R., M.A.A.-P., S.J.B.,
and R.Z.G. analyzed data; and A.P.B., M.M.L., J.R.S., I.D.W., S.A.M., J.M.R., R.Z.G.,
and M.R.R. wrote the paper.
1Present address: Symberix, Inc., Durham, NC 27703.
Author information
Article
Publisher ID:
201918095
DOI: 10.1073/pnas.1918095117
PMC ID: 7132129
PubMed ID: 32170007
SO-VID: 2bd0411e-8edb-4902-a349-e86bd43144eb
Copyright © Copyright © 2020 the Author(s). Published by PNAS.
Funded by: HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
100000062
Award ID: T32-DK007737
Award Recipient
: Aadra Prashant Bhatt
Award Recipient
: M. Andrea Azcarate-Peril
Award Recipient
: R. Balfour Sartor
Funded by: HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
100000062
Award ID: P30 DK034987
Award Recipient
: Aadra Prashant Bhatt
Award Recipient
: M. Andrea Azcarate-Peril
Award Recipient
: R. Balfour Sartor
Funded by: HHS | NIH | National Cancer Institute (NCI)
100000054
Award ID: CA207416
Award Recipient
: Scott J. Bultman
Award Recipient
: Matthew R. Redinbo
Funded by: HHS | NIH | National Cancer Institute (NCI)
100000054
Award ID: CA098468
Award Recipient
: Scott J. Bultman
Award Recipient
: Matthew R. Redinbo
Funded by: U.S. Department of Agriculture (USDA)
100000199
Award ID: 055336
Award Recipient
: Scott J. Bultman
Funded by: HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
100000062
Award ID: P40 OD010995
Award Recipient
: Aadra Prashant Bhatt
Award Recipient
: M. Andrea Azcarate-Peril
Award Recipient
: R. Balfour Sartor