Contributors
Jialiang Guo: Role: ConceptualizationRole: ResourcesRole: VisualizationRole: Writing – original
draftRole: Writing – review & editing
Qi Zhang: Role: Funding acquisition
Jia Li: Role: Investigation
Yansong Liu: Role: Methodology
Zhiyong Hou: Role: MethodologyRole: Supervision
Wei Chen: Role: Formal analysisRole: Methodology
Lin Jin: Role: Visualization
Ye Tian: Role: Software
Linlin Ju: Role: Data curation
Bo Liu: Role: InvestigationRole: Methodology
Tianhua Dong: Role: Resources
Fei Zhang: Role: Data curation
Yingze Zhang:
ORCID: http://orcid.org/0000-0001-7400-5216
Role: ConceptualizationRole: Funding acquisitionRole: MethodologyRole: Project administrationRole:
Validation
Chunfeng Zhao: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
6
November
2017
Publication date Collection: 2017
Volume: 12
Issue: 11
Electronic Location Identifier: e0187683
Affiliations
[1
]
Department of Orthopaedic Surgery, the Third Hospital of Hebei Medical University,
Shijiazhuang, P. R., China
[2
]
Key Laboratory of Orthopaedic Biomechanics of Hebei Province, Shijiazhuang, P. R.,
China
[3
]
Orthopaedic Research Institution of Hebei Province, Hebei, P. R., China
[4
]
VSD Medical Science & Technology Co., Ltd, Hubei, P. R., China
Mayo Clinic Minnesota, UNITED STATES
Author notes
Competing Interests: We have the following interests: Author YL was employed by VSD Medical Science & Technology
Co., Ltd, during the course of the study. There are no patents, products in development
or marketed products to declare. This does not alter our adherence to all the PLOS
ONE policies on sharing data and materials.
Author information
Article
Publisher ID:
PONE-D-17-19103
DOI: 10.1371/journal.pone.0187683
PMC ID: 5673204
PubMed ID: 29108027
SO-VID: 2a98e07c-9965-4054-a232-4cb08e309e6f
Copyright © © 2017 Guo et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 19
May
2017
Date
accepted
: 24
October
2017
Page count
Figures: 7,
Tables: 1,
Pages: 22
Funding
Funded by: Hebei Provincial 333 Talent Projection Foundation of China
Award ID: A2016015062
Award Recipient
:
Qi Zhang
The authors acknowledge the support from Hebei Provincial 333 Talent Projection Foundation
of China (No. A2016015062) (QZ). The funder had no role in study design, data collection
and analysis, decision to publish, or preparation of the manuscript. Author YL was
employed by VSD Medical Science & Technology Co., Ltd, during the course of the study.
The commercial company VSD Medical Science & Technology Co., Ltd had no direct relation
with this experiment. The author from VSD is a senior fellow apprentice of the first
author who focused on basal experiment in his doctor research, and he guided the procedure
of ovariectomy before conducting this experiment. He has left the company now, and
has a job in another company. The author did not play a role in the process of the
experiment. VSD Medical Science & Technology Co., Ltd, provided support in the form
of salary for author YL, but did not have any additional role in the study design,
data collection and analysis, decision to publish, or preparation of the manuscript.
The specific role of this author is articulated in the ‘author contributions’ section.
Categories
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Critical Care and Emergency Medicine
Subject:
Trauma Medicine
Subject:
Traumatic Injury
Subject:
Bone Fracture
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Collagens
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Physiological Processes
Subject:
Bone Remodeling
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Physiological Processes
Subject:
Bone Remodeling
Subject:
Medicine and Health Sciences
Subject:
Surgical and Invasive Medical Procedures
Subject:
Reproductive System Procedures
Subject:
Ovariectomy
Subject:
Medicine and Health Sciences
Subject:
Surgical and Invasive Medical Procedures
Subject:
Surgical Excision
Subject:
Ovariectomy
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Physiological Processes
Subject:
Tissue Repair
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Physiological Processes
Subject:
Tissue Repair
Subject:
Medicine and Health Sciences
Subject:
Pharmaceutics
Subject:
Drug Delivery
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Bone
Subject:
Bone Density
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Bone
Subject:
Bone Density
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Bone
Subject:
Bone Density
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Bone
Subject:
Bone Density
Subject:
Biology and Life Sciences
Subject:
Developmental Biology
Subject:
Organism Development
Subject:
Organogenesis
Subject:
Bone Development
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