A review of the properties and applications of bioadhesive hydrogels

Author(s): Yingshuo Xiong ¹ ^, ² ^, ³ ^, ⁴ , Xiaoran Zhang ¹ ^, ² ^, ³ ^, ⁴ , Xintao Ma ¹ ^, ² ^, ³ ^, ⁴ , Wenqi Wang ¹ ^, ² ^, ³ ^, ⁴ , Feiyan Yan ¹ ^, ² ^, ³ ^, ⁴ , Xiaohan Zhao ¹ ^, ² ^, ³ ^, ⁴ , Xiaoxiao Chu ¹ ^, ² ^, ³ ^, ⁴ , Wenlong Xu ¹ ^, ² ^, ³ ^, ⁴ , Changmei Sun ¹ ^, ² ^, ³ ^, ⁴

Publication date (Electronic): 2021

Journal: Polymer Chemistry

Publisher: Royal Society of Chemistry (RSC)

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Abstract

Due to their outstanding properties, bioadhesive hydrogels have been extensively studied by researchers in recent years.

Abstract

Due to their outstanding properties, bioadhesive hydrogels have been extensively studied by researchers in recent years. By designing the properties of bioadhesive hydrogels, they can be reasonably applied to biomedicine. Therefore, this practicality has prompted the birth of many bioadhesive hydrogels with excellent properties. In this review, by studying the progress in the field of bioadhesive hydrogels, we summarized the properties of hydrogels in bioadhesion, including adhesion, biocompatibility, degradability and antibacterial properties. In addition, we also summarized the applications of bioadhesive hydrogels in wound dressings, tissue repair, cell adhesion and wearable sensors. Finally, we summarized and outlooked the research on bioadhesive hydrogels, hoping to provide a valuable reference for the progress in the field of bioadhesive hydrogels.

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Yu Shrike Zhang, Ali Khademhosseini (2017)

Hydrogels are formed from hydrophilic polymer chains surrounded by a water-rich environment. They have widespread applications in various fields such as biomedicine, soft electronics, sensors, and actuators. Conventional hydrogels usually possess limited mechanical strength and are prone to permanent breakage. Further, the lack of dynamic cues and structural complexity within the hydrogels has limited their functions. Recent developments include engineering hydrogels that possess improved physicochemical properties, ranging from designs of innovative chemistries and compositions to integration of dynamic modulation and sophisticated architectures. We review major advances in designing and engineering hydrogels and strategies targeting precise manipulation of their properties across multiple scales.

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Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing

Tianlong Zhang, Jin Qu, Xin Zhao … (2018)

Designing wound dressing materials with outstanding therapeutic effects, self-healing, adhesiveness and suitable mechanical property has great practical significance in healthcare, especially for joints skin wound healing. Here, we designed a kind of self-healing injectable micelle/hydrogel composites with multi-functions as wound dressing for joint skin damage. By combining the dynamic Schiff base and copolymer micelle cross-linking in one system, a series of hydrogels were prepared by mixing quaternized chitosan (QCS) and benzaldehyde-terminated Pluronic®F127 (PF127-CHO) under physiological conditions. The inherent antibacterial property, pH-dependent biodegradation and release behavior were investigated to confirm multi-functions of wound dressing. The hydrogel dressings showed suitable stretchable and compressive property, comparable modulus with human skin, good adhesiveness and fast self-healing ability to bear deformation. The hydrogels exhibited efficient hemostatic performance and biocompatibility. Moreover, the curcumin loaded hydrogel showed good antioxidant ability and pH responsive release profiles. In vivo experiments indicated that curcumin loaded hydrogels significantly accelerated wound healing rate with higher granulation tissue thickness and collagen disposition and upregulated vascular endothelial growth factor (VEGF) in a full-thickness skin defect model. Taken together, the antibacterial adhesive hydrogels with self-healing and good mechanical property offer significant promise as dressing materials for joints skin wound healing.