Artificial intelligence for colorectal neoplasia detection during colonoscopy: a systematic review and meta-analysis of randomized clinical trials

Summary

Background

The use of artificial intelligence (AI) in detecting colorectal neoplasia during colonoscopy holds the potential to enhance adenoma detection rates (ADRs) and reduce adenoma miss rates (AMRs). However, varied outcomes have been observed across studies. Thus, this study aimed to evaluate the potential advantages and disadvantages of employing AI-aided systems during colonoscopy.

Methods

Using Medical Subject Headings (MeSH) terms and keywords, a comprehensive electronic literature search was performed of the Embase, Medline, and the Cochrane Library databases from the inception of each database until October 04, 2023, in order to identify randomized controlled trials (RCTs) comparing AI-assisted with standard colonoscopy for detecting colorectal neoplasia. Primary outcomes included AMR, ADR, and adenomas detected per colonoscopy (APC). Secondary outcomes comprised the poly missed detection rate (PMR), poly detection rate (PDR), and poly detected per colonoscopy (PPC). We utilized random-effects meta-analyses with Hartung-Knapp adjustment to consolidate results. The prediction interval (PI) and I ² statistics were utilized to quantify between-study heterogeneity. Moreover, meta-regression and subgroup analyses were performed to investigate the potential sources of heterogeneity. This systematic review and meta-analysis is registered with PROSPERO (CRD42023428658).

Findings

This study encompassed 33 trials involving 27,404 patients. Those undergoing AI-aided colonoscopy experienced a significant decrease in PMR (RR, 0.475; 95% CI, 0.294–0.768; I ²  = 87.49%) and AMR (RR, 0.495; 95% CI, 0.390–0.627; I ²  = 48.76%). Additionally, a significant increase in PDR (RR, 1.238; 95% CI, 1.158–1.323; I ²  = 81.67%) and ADR (RR, 1.242; 95% CI, 1.159–1.332; I ²  = 78.87%), along with a significant increase in the rates of PPC (IRR, 1.388; 95% CI, 1.270–1.517; I ²  = 91.99%) and APC (IRR, 1.390; 95% CI, 1.277–1.513; I ²  = 86.24%), was observed. This resulted in 0.271 more PPCs (95% CI, 0.144–0.259; I ²  = 65.61%) and 0.202 more APCs (95% CI, 0.144–0.259; I ²  = 68.15%).

Interpretation

AI-aided colonoscopy significantly enhanced the detection of colorectal neoplasia detection, likely by reducing the miss rate. However, future studies should focus on evaluating the cost-effectiveness and long-term benefits of AI-aided colonoscopy in reducing cancer incidence.

Funding

This work was supported by the doi 10.13039/501100005046, Heilongjiang Provincial Natural Science Foundation of China; (LH2023H096), the Postdoctoral research project in Heilongjiang Province (LBH-Z22210), the National Natural Science Foundation of China’s General Program (82072640) and the Outstanding Youth Project of Heilongjiang Natural Science Foundation (YQ2021H023).