SCOP: a structural classification of proteins database. – ScienceOpen
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      SCOP: a structural classification of proteins database.

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          Abstract

          The Structural Classification of Proteins (SCOP) database provides a detailed and comprehensive description of the relationships of known protein structures. The classification is on hierarchical levels: the first two levels, family and superfamily, describe near and distant evolutionary relationships; the third, fold, describes geometrical relationships. The distinction between evolutionary relationships and those that arise from the physics and chemistry of proteins is a feature that is unique to this database so far. The sequences of proteins in SCOP provide the basis of the ASTRAL sequence libraries that can be used as a source of data to calibrate sequence search algorithms and for the generation of statistics on, or selections of, protein structures. Links can be made from SCOP to PDB-ISL: a library containing sequences homologous to proteins of known structure. Sequences of proteins of unknown structure can be matched to distantly related proteins of known structure by using pairwise sequence comparison methods to find homologues in PDB-ISL. The database and its associated files are freely accessible from a number of WWW sites mirrored from URL http://scop.mrc-lmb.cam.ac.uk/scop/

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          Author and article information

          Journal
          Nucleic Acids Res
          Nucleic acids research
          Oxford University Press (OUP)
          0305-1048
          0305-1048
          Jan 01 2000
          : 28
          : 1
          Affiliations
          [1 ] MRC Laboratory of Molecular Biology, Centre for Protein Engineering, Hills Road, Cambridge CB2 2QH, UK. loredana@mrc-lmb.cam.ac.uk
          Article
          gkd097
          10.1093/nar/28.1.257
          102479
          10592240
          2969b291-693c-4740-8db2-057bef4ba88b
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