Contributors
Nobutoshi Nawa: Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: Writing – original
draftRole: Writing – review & editing
Katsuya Hirata: Role: InvestigationRole: Writing – review & editing
Keiji Kawatani: Role: InvestigationRole: Writing – review & editing
Toshihiko Nambara: Role: InvestigationRole: Writing – review & editing
Sayaka Omori: Role: InvestigationRole: Writing – review & editing
Kimihiko Banno: Role: InvestigationRole: Writing – review & editing
Chikara Kokubu: Role: MethodologyRole: SupervisionRole: Writing – review & editing
Junji Takeda: Role: MethodologyRole: SupervisionRole: Writing – review & editing
Ken Nishimura: Role: MethodologyRole: Writing – review & editing
Manami Ohtaka: Role: MethodologyRole: Writing – review & editing
Mahito Nakanishi: Role: MethodologyRole: Writing – review & editing
Daisuke Okuzaki: Role: Formal analysisRole: MethodologyRole: Writing – review & editing
Hidetoshi Taniguchi: Role: ResourcesRole: Writing – review & editing
Hitomi Arahori: Role: ResourcesRole: Writing – review & editing
Kazuko Wada: Role: ResourcesRole: Writing – review & editing
Yasuji Kitabatake:
ORCID: http://orcid.org/0000-0002-2907-9512
Role: ConceptualizationRole: Funding acquisitionRole: SupervisionRole: Writing – original
draftRole: Writing – review & editing
Keiichi Ozono: Role: SupervisionRole: Writing – review & editing
Marie-Claude Potier: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
29
July
2019
Publication date Collection: 2019
Volume: 14
Issue: 7
Electronic Location Identifier: e0219592
Affiliations
[1
]
Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka,
Japan
[2
]
Department of Neonatal Medicine, Osaka Women’s and Children’s Hospital, Izumi, Osaka,
Japan
[3
]
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana,
United States of America
[4
]
Department of Genome Biology, Graduate School of Medicine, Osaka University, Suita,
Osaka, Japan
[5
]
Laboratory of Gene Regulation, Faculty of Medicine, University of Tsukuba, Tsukuba,
Ibaraki, Japan
[6
]
Biotechnology Research Institute for Drug Discovery, National Institute of Advanced
Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan
[7
]
Genome Information Research Center, Research Institute for Microbial Diseases, Osaka
University, Suita, Osaka, Japan
Institut du cerveau et de la moelle epiniere, FRANCE
Author notes
Competing Interests: The authors have read the journal's policy and have the following competing interests:
This study received funding from Mitsui Life Social Welfare Foundation, and Shionogi
& Co., Ltd. Dr. Mahito Nakanishi is the founder and chief technology officer (CTO)
of Tokiwa-Bio, Inc. Method to generate iPS cells with SeVdp vector installing reprogramming
genes is protected by following patents: JP 4936482; JP 5633075; JP 5963309; US 9145564;
US 8496941 B2; US 9365866 B2; EP 2434012; EP 2639297. This does not alter our adherence
to all the PLOS ONE policies on sharing data and materials.
Author information
Article
Publisher ID:
PONE-D-18-29320
DOI: 10.1371/journal.pone.0219592
PMC ID: 6663065
PubMed ID: 31356639
SO-VID: 28a2dc21-11f6-400b-a250-1450e15df587
Copyright © © 2019 Nawa et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 9
October
2018
Date
accepted
: 27
June
2019
Page count
Figures: 6,
Tables: 0,
Pages: 24
Funding
Funded by: funder-id http://dx.doi.org/10.13039/100009619, Japan Agency for Medical Research and Development;
Award ID: JP18bm0804009
Award Recipient
:
ORCID: http://orcid.org/0000-0002-2907-9512
Yasuji Kitabatake
Funded by: funder-id http://dx.doi.org/10.13039/501100001691, Japan Society for the Promotion of Science;
Award ID: JP16K10090
Award Recipient
:
ORCID: http://orcid.org/0000-0002-2907-9512
Yasuji Kitabatake
This work was supported by the Practical Research Project for Rare/Intractable Diseases
from the Japan Agency for Medical Research and Development (AMED) (JP18bm0804009 to
Y.K.) and JSPS KAKENHI (JP16K10090 to Y.K.). This work was also supported by the grants
from Mitsui Life Social Welfare Foundation, and Shionogi & Co., Ltd. Additionally,
Tokiwa-Bio, Inc. provided support in the form of salary for author MN, but did not
have any additional role in the study design, data collection and analysis, decision
to publish, or preparation of the manuscript. The specific role of this author is
articulated in the ‘author contributions’ section. The funders had no role in study
design, data collection and analysis, decision to publish, or preparation of the manuscript.
Categories
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Connective Tissue Cells
Subject:
Fibroblasts
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Connective Tissue Cells
Subject:
Fibroblasts
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Connective Tissue Cells
Subject:
Fibroblasts
Subject:
Medicine and Health Sciences
Subject:
Clinical Genetics
Subject:
Chromosomal Disorders
Subject:
Down Syndrome
Subject:
Research and Analysis Methods
Subject:
Biological Cultures
Subject:
Cell Lines
Subject:
Cultured Fibroblasts
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Gene Expression
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Stem Cells
Subject:
Induced Pluripotent Stem Cells
Subject:
Medicine and Health Sciences
Subject:
Clinical Genetics
Subject:
Chromosomal Disorders
Subject:
Edwards Syndrome
Subject:
Research and Analysis Methods
Subject:
Chemical Synthesis
Subject:
Biosynthetic Techniques
Subject:
Protein Synthesis
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Protein Synthesis
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Bioenergetics
Subject:
Energy-Producing Organelles
Subject:
Mitochondria
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Structures and Organelles
Subject:
Energy-Producing Organelles
Subject:
Mitochondria
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