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Comparison of the effect of terlipressin and albumin on arterial blood volume in patients with cirrhosis and tense ascites treated by paracentesis: a randomised pilot study.
R Moreau
1 ,
T Asselah ,
B Condat ,
C de Kerguenec ,
F Pessione ,
B Bernard ,
T Poynard ,
M Binn ,
J D Grangé ,
D Valla ,
D Lebrec
Jan 2002
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Abstract
Patients with cirrhosis and tense ascites treated by paracentesis alone have a decrease in effective arterial blood volume after ascites removal. Although intravenous albumin is effective in preventing paracentesis induced decreased arterial blood volume, its clinical use is controversial. As paracentesis induces arteriolar vasodilation which plays a role in the development of decreased effective arterial blood volume, administration of a vasoconstrictor (terlipressin) could prevent circulatory alterations due to paracentesis.