Engineering materials for pyroptosis induction in cancer treatment

Abstract

Cancer remains a significant global health concern, necessitating the development of innovative therapeutic strategies. This research paper aims to investigate the role of pyroptosis induction in cancer treatment. Pyroptosis, a form of programmed cell death characterized by the release of pro-inflammatory cytokines and the formation of plasma membrane pores, has gained significant attention as a potential target for cancer therapy. The objective of this study is to provide a comprehensive overview of the current understanding of pyroptosis and its role in cancer treatment. The paper discusses the concept of pyroptosis and its relationship with other forms of cell death, such as apoptosis and necroptosis. It explores the role of pyroptosis in immune activation and its potential for combination therapy. The study also reviews the use of natural, biological, chemical, and multifunctional composite materials for pyroptosis induction in cancer cells. The molecular mechanisms underlying pyroptosis induction by these materials are discussed, along with their advantages and challenges in cancer treatment. The findings of this study highlight the potential of pyroptosis induction as a novel therapeutic strategy in cancer treatment and provide insights into the different materials and mechanisms involved in pyroptosis induction.

Graphical abstract

Highlights

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  Pyroptosis induction via engineering materials often sparks immune responses.

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  GSDM and caspases play key roles in pyroptosis molecular mechanisms.

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  Natural materials in pyroptosis reveal dual facets in cancer therapy.

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  Viruses and bacteria hold potential for inducing pyroptosis as biological agents.

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  Advantages and challenges in applying engineering materials in cancer therapy.