Decreased Fecal Bacterial Diversity and Altered Microbiome in Children Colonized With Clostridium difficile.

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Abstract

The gut microbiome is believed to play a role in the susceptibility to and treatment of Clostridium difficile infections (CDIs). It is, however, unknown whether the gut microbiome is also affected by asymptomatic C difficile colonization. Our study aimed to evaluate the fecal microbiome of children based on C difficile colonization, and CDI risk factors, including antibiotic use and comorbid inflammatory bowel disease (IBD).

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Journal

Journal ID (iso-abbrev): J Pediatr Gastroenterol Nutr

Title: Journal of pediatric gastroenterology and nutrition

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1536-4801

ISSN (Print): 0277-2116

Publication date (Electronic): April 2019

Volume: 68

Issue: 4

Affiliations

[1 ] Department of Medicine, Division of Gastroenterology, New York University School of Medicine, New York, NY.

[2 ] Johns Hopkins School of Medicine, Baltimore, MD.

[3 ] Department of Medicine, New York University School of Medicine.

[4 ] Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.

[5 ] The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ.

[6 ] Department of Physical Medicine and Rehabilitation, Pikeville Medical Center, Pikeville, KY.

[7 ] Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cedars-Sinai Hospital, Los Angeles, CA.

[8 ] Division of Gastroenterology, Boonshoft School of Medicine, Wright State University, Dayton Children's Hospital, Dayton, OH.

[9 ] Department of Medicine, University of Alabama at Birmingham, Birmingham, AL.

[10 ] Division of Pediatric Gastroenterology, Hepatology and Nutrition.

[11 ] Department of Medicine, Johns Hopkins University School of Medicine.

[12 ] Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD.

Article

DOI: 10.1097/MPG.0000000000002210

PubMed ID: 30540709

SO-VID: 2798b634-be7f-4f4b-81e6-b4d95177538f

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