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Histone modifications in transcriptional regulation
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Abstract
Covalent modifications of the amino termini of the core histones in nucleosomes have
important roles in gene regulation. Research in the past two years reveals these modifications
to consist of phosphorylation, methylation and ubiquitination, in addition to the
better-characterized acetylation. This multiplicity of modifications, and their occurrence
in patterns and dependent sequences, argues persuasively for the existence of a histone
code.