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      Longer Hospitalizations and Higher In-Hospital Mortality for Acute Heart Failure during the COVID-19 Pandemic in Larger vs. Smaller Cardiology Departments: Subanalysis of the COV-HF-SIRIO 6 Multicenter Study

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      1 , * , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 3 , 31 , 32 , 33 , 34 , 35 , 34 , 36 , 20 , 20 , 37 , 38 , 1
      Reviews in Cardiovascular Medicine
      IMR Press
      acute heart failure, COVID-19, hospitalization, in-hospital mortality

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          Abstract

          Background:

          The coronavirus disease-2019 (COVID-19) pandemic is surging across Poland, leading to many direct deaths and underestimated collateral damage. We aimed to compare the influence of the COVID-19 pandemic on hospital admissions and in-hospital mortality in larger vs. smaller cardiology departments (i.e., with 2000 vs. < 2000 hospitalizations per year in 2019).

          Methods:

          We performed a subanalysis of the COV-HF-SIRIO 6 multicenter retrospective study including all patients hospitalized in 24 cardiology departments in Poland between January 1, 2019 and December 31, 2020, focusing on patients with acute heart failure (AHF) and COVID-19.

          Results:

          Total number of hospitalizations was reduced by 29.2% in larger cardiology departments and by 27.3% in smaller cardiology departments in 2020 vs. 2019. While hospitalizations for AHF were reduced by 21.8% and 25.1%, respectively. The length of hospital stay due to AHF in 2020 was 9.6 days in larger cardiology departments and 6.6 days in smaller departments ( p < 0.001). In-hospital mortality for AHF during the COVID-19 pandemic was significantly higher in larger vs. smaller cardiology departments (10.7% vs. 3.2%; p < 0.001). In-hospital mortality for concomitant AHF and COVID-19 was extremely high in larger and smaller cardiology departments accounting for 31.3% vs. 31.6%, respectively.

          Conclusions:

          During the COVID-19 pandemic longer hospitalizations and higher in-hospital mortality for AHF were observed in larger vs. smaller cardiology departments. Reduced hospital admissions and extremely high in-hospital mortality for concomitant AHF and COVID-19 were noted regardless of department size.

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          Most cited references36

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          2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC.

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            Reduced Rate of Hospital Admissions for ACS during Covid-19 Outbreak in Northern Italy

            To the Editor: To address the coronavirus (Covid-19) pandemic, 1 strict social containment measures have been adopted worldwide, and health care systems have been reorganized to cope with the enormous increase in the numbers of acutely ill patients. 2,3 During this same period, some changes in the pattern of hospital admissions for other conditions have been noted. The aim of the present analysis is to investigate the rate of hospital admissions for acute coronary syndrome (ACS) during the early days of the Covid-19 outbreak. In this study, we performed a retrospective analysis of clinical and angiographic characteristics of consecutive patients who were admitted for ACS at 15 hospitals in northern Italy. All the hospitals were hubs of local networks for treatment involving primary percutaneous coronary intervention. The study period was defined as the time between the first confirmed case of Covid-19 in Italy (February 20, 2020) and March 31, 2020. We compared hospitalization rates between the study period and two control periods: a corresponding period during the previous year (February 20 to March 31, 2019) and an earlier period during the same year (January 1 to February 19, 2020). The primary outcome was the overall rate of hospital admissions for ACS. We calculated incidence rates for the primary outcome by dividing the number of cumulative admissions by the number of days for each time period. Incidence rate ratios comparing the study period with each of the control periods were calculated with the use of Poisson regression. (Details regarding the study methods are provided in the Supplementary Appendix, available with the full text of this letter at NEJM.org.) Of the 547 patients who were hospitalized for ACS during the study period, 420 (76.8%) were males; the mean (±SD) age was 68±12 years. Of these patients, 248 (45.3%) presented with ST-segment elevation myocardial infarction (STEMI). The mean admission rate for ACS during the study period was 13.3 admissions per day. This rate was significantly lower than either the rate during the earlier period in the same year (total number of admissions, 899; 18.0 admissions per day; incidence rate ratio, 0.74; 95% confidence interval [CI], 0.66 to 0.82; P<0.001) or the rate during the previous year (total number of admissions, 756; 18.9 admissions per day; incidence rate ratio, 0.70; 95% CI, 0.63 to 0.78; P<0.001). The incidence rate ratios for individual ACS subtypes are presented in Table 1. After the national lockdown was implemented on March 8, 2020, 4 a further reduction in ACS admissions was reported. (Details regarding the full secondary analyses are provided in the Supplementary Appendix.) This report shows a significant decrease in ACS-related hospitalization rates across several cardiovascular centers in northern Italy during the early days of the Covid-19 outbreak. Recent data suggest a significant increase in mortality during this period that was not fully explained by Covid-19 cases alone. 5 This observation and data from our study raise the question of whether some patients have died from ACS without seeking medical attention during the Covid-19 pandemic.
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              COVID-19 pandemic and admission rates for and management of acute coronary syndromes in England

              Summary Background Several countries affected by the COVID-19 pandemic have reported a substantial drop in the number of patients attending the emergency department with acute coronary syndromes and a reduced number of cardiac procedures. We aimed to understand the scale, nature, and duration of changes to admissions for different types of acute coronary syndrome in England and to evaluate whether in-hospital management of patients has been affected as a result of the COVID-19 pandemic. Methods We analysed data on hospital admissions in England for types of acute coronary syndrome from Jan 1, 2019, to May 24, 2020, that were recorded in the Secondary Uses Service Admitted Patient Care database. Admissions were classified as ST-elevation myocardial infarction (STEMI), non-STEMI (NSTEMI), myocardial infarction of unknown type, or other acute coronary syndromes (including unstable angina). We identified revascularisation procedures undertaken during these admissions (ie, coronary angiography without percutaneous coronary intervention [PCI], PCI, and coronary artery bypass graft surgery). We calculated the numbers of weekly admissions and procedures undertaken; percentage reductions in weekly admissions and across subgroups were also calculated, with 95% CIs. Findings Hospital admissions for acute coronary syndrome declined from mid-February, 2020, falling from a 2019 baseline rate of 3017 admissions per week to 1813 per week by the end of March, 2020, a reduction of 40% (95% CI 37–43). This decline was partly reversed during April and May, 2020, such that by the last week of May, 2020, there were 2522 admissions, representing a 16% (95% CI 13–20) reduction from baseline. During the period of declining admissions, there were reductions in the numbers of admissions for all types of acute coronary syndrome, including both STEMI and NSTEMI, but relative and absolute reductions were larger for NSTEMI, with 1267 admissions per week in 2019 and 733 per week by the end of March, 2020, a percent reduction of 42% (95% CI 38–46). In parallel, reductions were recorded in the number of PCI procedures for patients with both STEMI (438 PCI procedures per week in 2019 vs 346 by the end of March, 2020; percent reduction 21%, 95% CI 12–29) and NSTEMI (383 PCI procedures per week in 2019 vs 240 by the end of March, 2020; percent reduction 37%, 29–45). The median length of stay among patients with acute coronary syndrome fell from 4 days (IQR 2–9) in 2019 to 3 days (1–5) by the end of March, 2020. Interpretation Compared with the weekly average in 2019, there was a substantial reduction in the weekly numbers of patients with acute coronary syndrome who were admitted to hospital in England by the end of March, 2020, which had been partly reversed by the end of May, 2020. The reduced number of admissions during this period is likely to have resulted in increases in out-of-hospital deaths and long-term complications of myocardial infarction and missed opportunities to offer secondary prevention treatment for patients with coronary heart disease. The full extent of the effect of COVID-19 on the management of patients with acute coronary syndrome will continue to be assessed by updating these analyses. Funding UK Medical Research Council, British Heart Foundation, Public Health England, Health Data Research UK, and the National Institute for Health Research Oxford Biomedical Research Centre.
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                Author and article information

                Contributors
                Role: Academic Editor
                Journal
                Rev Cardiovasc Med
                RCM
                Reviews in Cardiovascular Medicine
                IMR Press
                2153-8174
                1530-6550
                24 August 2022
                September 2022
                : 23
                : 9
                : 292
                Affiliations
                [1] 1Collegium Medicum, Nicolaus Copernicus University, 85-094 Bydgoszcz, Poland
                [2] 2Department of Cardiology, Marian Zyndram-Kościałkowski Ministry of Interior and Administration Hospital, 15-471 Białystok, Poland
                [3] 3Department of Cardiology, Chair of Cardiology and Cardiac Surgery, Medical University of Lodz, 92-213 łódź, Poland
                [4] 4Department of Cardiology, Hospital of the Ministry of Interior and Administration, 35-111 Rzeszów, Poland
                [5] 51st Department of Cardiology, Collegium Medicum, Jan Kochanowski University, 25-736 Kielce, Poland
                [6] 6Department of Cardiology and Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 11-041 Olsztyn, Poland
                [7] 7Department of Cardiology and Cardiac Surgery, 10th Military Hospital and Polyclinic, 85-681 Bydgoszcz, Poland
                [8] 8Department of Cardiology Independent Public Healthcare in Przeworsk, 37-200 Przeworsk, Poland
                [9] 9Institute of Humanities and Medicine, Academy of Zamosc, 22-400 Zamość, Poland
                [10] 10Cardiology Department, Medical Care Center, 37-500 Jaroslaw, Poland
                [11] 11Department of Cardiology and Internal Diseases, Institute of Maritime and Tropical Medicine, Medical University of Gdansk, 81-519 Gdynia, Poland
                [12] 12Department of Cardiology, Tertiary Care Hospital, 06-400 Ciechanów, Poland
                [13] 13Department of Cardiology, Masovian Rehabilitation Center “STOCER”, Dr Włodzimierz Roefler Hospital, 05-800 Pruszków, Poland
                [14] 14Department of Cardiology, District Hospital, 89-500 Tuchola, Poland
                [15] 15Department of Cardiology, Dr. Emil Warmiński Tertiary Care Municipal Hospital, 85-808 Bydgoszcz, Poland
                [16] 16Department of Invasive Cardiology, Central Clinical Hospital of the Ministry of Interior and Administration, 02-507 Warsaw, Poland
                [17] 17Mossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, Poland
                [18] 18Department of Cardiology, Polish Hospitals, 47-200 Kędzierzyn-Koźle, Poland
                [19] 19Department of Cardiology and Intensive Cardiac Care Unit, District Polyclinic Hospital, 87-100 Toruń, Poland
                [20] 20Department of Cardiology, Medical University of Białystok, 15-276 Białystok, Poland
                [21] 21Department of Cardiology and Cardiac Intensive Care, Tertiary Care Municipal Hospital, 87-100 Toruń, Poland
                [22] 22Cardiology Subdivision of Heart Failure. St. Elizabeth Hospital, 48-210 Biała, Poland
                [23] 23Department of Cardiology, Interventional Cardiology and Electrophysiology with Cardiac Intensive Care Unit, Tertiary Care Hospital, 86-300 Grudziądz, Poland
                [24] 241st Department of Physiology, Institute of Medical Sciences, University of Opole 2, Cardiology Center of Kluczbork SCANMED SA, 46-203 Kluczbork, Poland
                [25] 25Department of Cardiology, Polish Hospitals, 82-400 Sztum, Poland
                [26] 262nd Department of Cardiology, Collegium Medicum, Jagiellonian University, 30-688 Cracow, Poland
                [27] 27Department of Cardiology, Center of Postgraduate Medical Education, Grochowski Hospital, 04-073 Warsaw, Poland
                [28] 28Department of Kinesiology and Health Prevention, Jan Dlugosz University in Częstochowa, 42-200 Częstochowa, Poland
                [29] 29Gajda-Med District Hospital in Pultusk, 06-100 Pułtusk, Poland
                [30] 303rd Department of Cardiology, Silesian Center for Heart Diseases, Faculty of Medicine in Zabrze, Medical University of Silesia, 41-800 Zabrze, Poland
                [31] 311st Department of Cardiology, Medical University of Gdansk, 80-952 Gdańsk, Poland
                [32] 32Department of Internal Medicine and Geriatric Cardiology, Centre of Postgraduate Medical Education, 00-416 Warsaw, Poland
                [33] 33Department of Interventional Cardiology, Institute of Cardiology, Jagiellonian University Medical College, John Paul II Hospital in Krakow, 31-202 Cracow, Poland
                [34] 34Department of Cardiology, Poznan University of Medical Sciences, 61-848 Poznań, Poland
                [35] 35Department of Heart Failure and Transplantology, National Institute of Cardiology, 04-628 Warsaw, Poland
                [36] 36Department of Coronary Artery Disease and Heart Failure, Institute of Cardiology, Jagiellonian University Medical College, 31-202 Cracow, Poland
                [37] 37Department of Arterial Hypertension and Diabetology, Medical University of Gdansk, 80-952 Gdańsk, Poland
                [38] 38Department of Cardiology, Pomeranian Medical University, 71-899 Szczecin, Poland
                Author notes
                *Correspondence: m.ostrowska@ 123456cm.umk.pl (Małgorzata Ostrowska)
                Article
                S1530-6550(22)00656-1
                10.31083/j.rcm2309292
                11262386
                39077718
                26aec2dc-ccc7-4276-bd61-13f6e69f934f
                Copyright: © 2022 The Author(s). Published by IMR Press.

                This is an open access article under the CC BY 4.0 license.

                History
                : 12 June 2022
                : 27 July 2022
                : 4 August 2022
                Categories
                Original Research

                acute heart failure,covid-19,hospitalization,in-hospital mortality

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